Rodríguez C, Tomás A, Alves E, Ramirez O, Arqué M, Muñoz G, Barragán C, Varona L, Silió L, Amills M, Noguera J L
Departamento de Mejora Genética Animal, SGIT-INIA, Madrid 28040, Spain.
Anim Genet. 2005 Dec;36(6):490-6. doi: 10.1111/j.1365-2052.2005.01358.x.
The aim of this study was to investigate chromosomal regions affecting the number of teats in pigs and possible epistatic interactions between the identified quantitative trait loci (QTL). An experimental F2 cross between Iberian and Chinese Meishan lines was used for this purpose. A genomic scan was conducted with 117 markers covering the 18 porcine autosomes. Linkage analyses were performed by interval mapping using an animal model to estimate QTL and additive polygenic effects. Complementary analyses with models fitting two QTL were also carried out. The results showed three genomewide significant QTL mapping on chromosomes 5, 10 and 12, whose joint action control up to 30% of the phenotypic variance of the trait. Meishan alleles had a positive additive effect on teat number, and a positive-additive x additive-epistatic interaction was detected between QTL on chromosomes 10 and 12.
本研究旨在调查影响猪乳头数目的染色体区域，以及所鉴定的数量性状位点（QTL）之间可能存在的上位性相互作用。为此，使用伊比利亚猪和中国梅山猪品系进行了F2代杂交实验。利用覆盖18条猪常染色体的117个标记进行了基因组扫描。通过区间作图法，使用动物模型进行连锁分析，以估计QTL和加性多基因效应。还对拟合两个QTL的模型进行了补充分析。结果显示，在第5、10和12号染色体上发现了3个全基因组显著的QTL，它们的联合作用控制了该性状高达30%的表型变异。梅山猪等位基因对乳头数目具有正向加性效应，并且在第10号和12号染色体上的QTL之间检测到正向加性×加性上位性相互作用。
