由（核酸-稀土元素）络合物形成的液晶分散体颗粒作为中子俘获治疗的潜在平台。

Particles of liquid-crystalline dispersions formed by (nucleic acid-rare earth element) complexes as a potential platform for neutron capture therapy.

作者信息

Yevdokimov Yury M, Salyanov Victor I, Kondrashina Olga V, Borshevsky Valentin I, Semenov Sergey V, Gasanov Achmedali A, Reshetov Igor V, Kuznetsov Vjacheslav D, Nikiforov Vladimir N, Akulinichev Sergey V, Mordovskoi Mikhail V, Potashev Stanislav I, Skorkin Vladimir M

机构信息

Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Vavilova Str. 32, 119991 Moscow, Russia.

出版信息

Int J Biol Macromol. 2005 Dec 15;37(4):165-73. doi: 10.1016/j.ijbiomac.2005.10.001. Epub 2005 Nov 15.

DOI:10.1016/j.ijbiomac.2005.10.001

PMID:16293300

Abstract

Microscopic size particles of the cholesteric double-stranded DNA (RNA) liquid-crystalline dispersions, containing the ions of the rare earth elements in their content, have been obtained for the first time. The properties of these particles differ from those of classical DNA cholesterics noticeably. The local concentration of the rare earth elements in a particle reaches 200 mg/ml. The particles of the liquid-crystalline dispersion of the (DNA-gadolinium) complex maintain the properties for a long time. The combination of the microscopic size of particles, high concentration of gadolinium in particles and their stability opens a way to practical application of this new biomaterial.

摘要

首次获得了胆甾型双链DNA（RNA）液晶分散体的微观尺寸颗粒，其成分中含有稀土元素离子。这些颗粒的性质与经典DNA胆甾相明显不同。颗粒中稀土元素的局部浓度达到200mg/ml。（DNA-钆）复合物的液晶分散体颗粒能长时间保持其性质。颗粒的微观尺寸、颗粒中钆的高浓度及其稳定性的结合为这种新型生物材料的实际应用开辟了道路。