Jackson Joseph A, Turner Joseph D, Kamal Mahine, Wright Victoria, Bickle Quentin, Else Kathryn J, Ramsan Mahdi, Bradley Janette E
School of Biology, Nottingham University, Nottingham, UK.
Microbes Infect. 2006 Feb;8(2):487-92. doi: 10.1016/j.micinf.2005.07.025. Epub 2005 Oct 3.
Ex vivo monocyte cytokine responses (IL-1beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-exposed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-alpha and IL-1beta responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10, TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens.
在坦桑尼亚奔巴岛的47名暴露于胃肠道（GI）线虫的儿童中，对细菌TLR2和TLR4配体的离体单核细胞细胞因子反应（IL-1β、TNF-α、IL-12p70、IL-10、TGF-β）进行了定量分析。蠕虫感染程度（通过粪便虫卵计数（FEC）估算）与对TLR配体的促炎TNF-α和IL-1β反应呈正相关。特别是，与对TLR4配体（LPS）的TNF-α反应存在很强的显著相关性。调节性反应（IL-10、TGF-β）与蠕虫感染程度之间无显著关联。这些结果与胃肠道线虫调节先天性反应的可能性一致，可能表明胃肠道线虫病与重要旁观者病原体之间相互作用的潜在机制。
