Ramlal Ayyagari, Nautiyal Aparna, Kumar Jitendra, Mishra Vachaspati, Sogan Nisha, Nasser B Singab Abdel
Division of Genetics, ICAR-Indian Agricultural Research Institute (IARI), Pusa Campus, New Delhi, Delhi, India 110012.
School of Biological Sciences, Universiti Sains Malaysia (USM), Georgetown, Penang, Malaysia 11800.
Saudi J Biol Sci. 2023 Nov;30(11):103814. doi: 10.1016/j.sjbs.2023.103814. Epub 2023 Sep 26.
Ascariasis and intestinal parasitic nematodes are the leading cause of mass mortality infecting many people across the globe. In light of the various deleterious side effects of modern chemical-based allopathic drugs, our preferences have currently shifted towards the use of traditional plant-based drugs or botanicals for treating diseases. The defensive propensities in the botanicals against parasites have probably evolved during their co-habitation with parasites, humans and plants in nature and hence their combative interference in one another's defensive mechanisms has occurred naturally ultimately being very effective in treating diseases. This article broadly outlines the utility of plant-based compounds or botanicals prepared from various medicinal herbs that have the potential to be developed as effective therapies against the important parasites causing ascariasis and intestinal hookworm infections leading to ascariasis & infections and thereby human mortality, wherein allopathic treatments are less effective and causes enormous side-effects.
蛔虫病和肠道寄生线虫是导致全球许多人大量死亡的主要原因。鉴于现代化学合成的对抗疗法药物存在各种有害副作用,我们目前的偏好已转向使用传统的植物性药物或植物药来治疗疾病。植物药对寄生虫的防御倾向可能是在它们与寄生虫、人类和植物在自然界共同生存的过程中演变而来的,因此它们在彼此防御机制中的对抗干扰自然发生,最终在治疗疾病方面非常有效。本文大致概述了由各种草药制备的植物性化合物或植物药的效用,这些植物药有潜力被开发成有效的疗法,用于对抗导致蛔虫病和肠道钩虫感染进而引发蛔虫病及感染并导致人类死亡的重要寄生虫,而在这些疾病的治疗中,对抗疗法效果较差且会产生巨大的副作用。