内镜下向胃窦注射肉毒杆菌毒素治疗肥胖症：一项初步研究的结果

Endoscopic injection of botulinum toxin in the gastric antrum for the treatment of obesity. Results of a pilot study.

作者信息

García-Compean Diego, Mendoza-Fuerte Eduardo, Martínez Juan Antonio, Villarreal Irma, Maldonado Héctor

机构信息

Regional Center for the Study of Digestive Diseases, University Hospital. Faculty of Medicine, University Autonomous of Nuevo Leon, Mexico.

出版信息

Gastroenterol Clin Biol. 2005 Aug-Sep;29(8-9):789-91. doi: 10.1016/s0399-8320(05)86349-3.

DOI:10.1016/s0399-8320(05)86349-3

PMID:16294147

Abstract

OBJECTIVES

The aim of this study was to observe the effects of endoscopic injections of botulinum toxin (BT) in the gastric antrum on body weight and gastric emptying in obese patients.

PATIENTS AND METHODS

Obese patients were selected for the study. By endoscopy, 100 U of BT type A was injected into the prepyloric antral gastric wall. Before and after treatment body weight and solid gastric emptying were evaluated.

RESULTS

Twelve patients were included into this study. Four and twelve weeks after the treatment median values of body weight and gastric emptying did not show significant changes compared to baseline values: body weight: (- 0.5 kg and - 1.0 kg respectively, P > 0.05) and gastric retention for solids at 90 min (+ 4.5% and +10.5% respectively, P > 0.05). Abnormal gastric emptying (solid gastric retention at 90 min > 50%) was observed in 22% of patients after 4 weeks and in 25% after 12 weeks.

CONCLUSIONS

BT injected into the gastric antrum does not seem to significantly reduce body weight or delay gastric emptying in obese patients.

摘要

目的

本研究旨在观察内镜下向胃窦注射肉毒杆菌毒素（BT）对肥胖患者体重和胃排空的影响。

患者与方法

选择肥胖患者进行研究。通过内镜，将100单位A型肉毒杆菌毒素注射到幽门窦前胃壁。治疗前后评估体重和固体胃排空情况。

结果

12例患者纳入本研究。治疗后4周和12周，体重和胃排空的中位数与基线值相比无显著变化：体重分别为（-0.5千克和-1.0千克，P>0.05），90分钟时固体胃潴留分别为（+4.5%和+10.5%，P>0.05）。4周后22%的患者和12周后25%的患者观察到胃排空异常（90分钟时固体胃潴留>50%）。