Tang Wen-Lu, Wang Yong-Ming, Du Wen-Min, Cheng Neng-Neng, Chen Bin-Yan
Laboratory of Pharmacology, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Pharmacoepidemiol Drug Saf. 2006 Feb;15(2):123-30. doi: 10.1002/pds.1166.
The study was to assess the quality of life (QOL) of the elderly diabetes mellitus (DM) in Shanghai community and to screen the possible risk factors.
A total of 951 patients with elderly DM and 1007 elderly subjects with normal glucose tolerance from the same community as control group were enrolled in the study. A door-to-door retrospectively epidemiological survey was used to collect data of QOL, demographic, and diabetic information. The SF-36 instrument (Chinese edition) was used to assess QOL. Multiple stepwise linear regression analysis was also used to identify possible risk factors of QOL in elder DM.
In subjects with elderly DM, the general assessment of perceived health was worse, compared with the normal elderly people; the mean score of multi-item dimensions assessment had been decreased, the lowest and highest scores of which on SF-36, respectively, were general health and body pain (ranged from 42.08 to 77.00). Based on the multiple stepwise regression analysis, 23 risk factors entered 9 multiple regressive models (9 dependent variables of which stand for the scores of 8 dimensions and the total score on SF-36) with different amount ultimately. Within the 13 risk factors that affect QOL of the elderly diabetic patients, the negative correlated factors were gender, age, payment ability of medical treatment, tumor, level of fasting plasma glucose (FPG), medicines purchasing channels, diabetic microvascular complications, diabetic macrovascular complications, acute complications, while the positive correlated factors were occupation, income, exercises, knowledge of DM. The multiple correlation coefficient square (R2) represented the above 13 risk factors had a totally 30.5% impact on the entire QOL.
QOL of elderly DM population had significantly been decreased; QOL of the elderly patients in Shanghai community had many risk factors, which on one hand stated the complexity of elderly DM, and on the other hand gave us many useful and practical methods to improve QOL of elderly DM.
评估上海社区老年糖尿病患者的生活质量（QOL），并筛查可能的危险因素。
本研究纳入了951例老年糖尿病患者以及来自同一社区的1007例糖耐量正常的老年受试者作为对照组。采用上门回顾性流行病学调查收集生活质量、人口统计学和糖尿病相关信息。使用SF-36量表（中文版）评估生活质量。还采用多元逐步线性回归分析确定老年糖尿病患者生活质量的可能危险因素。
与正常老年人相比，老年糖尿病患者对自身健康的总体评价较差；多项维度评估的平均得分降低，SF-36量表中得分最低和最高的分别是总体健康和身体疼痛（范围为42.08至77.00）。基于多元逐步回归分析，23个危险因素最终进入9个多元回归模型（9个因变量分别代表SF-36量表8个维度的得分和总分）。在影响老年糖尿病患者生活质量的13个危险因素中，负相关因素为性别、年龄、医疗支付能力、肿瘤、空腹血糖（FPG）水平、购药渠道、糖尿病微血管并发症、糖尿病大血管并发症、急性并发症，而正相关因素为职业、收入、运动、糖尿病知识。多元相关系数平方（R²）表明上述13个危险因素对整体生活质量的总影响为30.5%。
老年糖尿病患者的生活质量显著下降；上海社区老年患者的生活质量存在诸多危险因素，这一方面表明老年糖尿病的复杂性，另一方面也为我们提供了许多改善老年糖尿病患者生活质量的实用方法。
