Tomaszewski C, Voorhees S, Wathen J, Brent J, Kulig K
Rocky Mountain Poison and Drug Center, Denver General Hospital, Colorado.
J Emerg Med. 1992 Jan-Feb;10(1):59-62. doi: 10.1016/0736-4679(92)90012-i.
Although activated charcoal (AC) is commonly used after ingestions of cocaine, the ability of AC to bind with this drug is unknown. We studied binding of cocaine to AC in vitro. Cocaine adsorption to charcoal for AC:drug ratios of 1:1, 2.5:1, and 5:1 at pH 1.2 was 40%, 92%, and 99%, respectively; at pH 8.0, it was 78%, 98%, and 99%, respectively. All means were significantly different (P less than 0.05) versus the control (no AC) at each pH. At the AC:drug ratio of 1:1, there was also significantly greater adsorption of cocaine at pH 8.0 than at pH 1.2. This study shows that AC strongly adsorbs cocaine under both acidic and alkaline conditions.
尽管活性炭（AC）常用于可卡因摄入后，但AC与这种药物结合的能力尚不清楚。我们在体外研究了可卡因与AC的结合情况。在pH值为1.2时，AC与药物比例为1:1、2.5:1和5:1时，可卡因对活性炭的吸附率分别为40%、92%和99%；在pH值为8.0时，分别为78%、98%和99%。在每个pH值下，所有平均值与对照组（无AC）相比均有显著差异（P小于0.05）。在AC与药物比例为1:1时，pH值为8.0时可卡因的吸附率也显著高于pH值为1.2时。这项研究表明，在酸性和碱性条件下，AC都能强烈吸附可卡因。
