Lang Niklaus P, Anton Elena, Gabriel Yvonne, Salvi Giovanni E, Pjetursson Bjarni E, Winston J Leslie, He Tao
University of Berne School of Dental Medicine, Berne, Switzerland.
Oral Health Prev Dent. 2004;2(4):369-76.
A double blind, controlled, parallel group trial utilizing the experimental gingivitis model was performed on thirty young adults to evaluate the clinical effects of a 0.45% stannous fluoride dentifrice used as a slurry on dental biofilm formation and the development of gingivitis.
Following a thorough examination and oral prophylaxis procedures, subjects were randomly assigned to apply one of the following dentifrices twice daily over a three-week period: A) dentifrice slurry without active ingredients; B) 0.45% stannous fluoride gel; and C) Colgate Total dentifrice slurry (0.30% triclosan, 0.24% sodium fluoride, 2% copolymer).
After three weeks, the stannous fluoride dentifrice significantly (p < 0.05) reduced gingivitis compared with the Colgate Total group by 39.7%. Gingival bleeding was also reduced relative to the Colgate Total group. This difference was statistically significant (P < 0.05). During the experimental period, the mean PII scores increased almost linearly in all three groups without yielding any statistically significant differences.
The results of this clinical trial demonstrated that, over a three-week period, the application of a 0.45% SnF2 gel significantly inhibited the onset of gingivitis compared to Triclosan/sodium fluoride/copolymer (Colgate Total). However, neither stannous fluoride nor Triclosan/sodium fluoride/ copolymer (Colgate Total) possessed sufficient antimicrobial activity to suppress biofilm formation in the absence of regular oral hygiene practices.
利用实验性牙龈炎模型，对30名年轻成年人进行了一项双盲、对照、平行组试验，以评估用作糊剂的0.45%氟化亚锡牙膏对牙菌斑形成和牙龈炎发展的临床效果。
在进行全面检查和口腔预防程序后，将受试者随机分配，在三周内每天两次使用以下牙膏之一：A）无活性成分的牙膏糊剂；B）0.45%氟化亚锡凝胶；C）高露洁全效牙膏糊剂（0.30%三氯生、0.24%氟化钠、2%共聚物）。
三周后，与高露洁全效组相比，氟化亚锡牙膏使牙龈炎显著降低（p<0.05），降低了39.7%。相对于高露洁全效组，牙龈出血也有所减少。这种差异具有统计学意义（P<0.05）。在实验期间，所有三组的平均菌斑指数（PII）得分几乎呈线性增加，未产生任何统计学上的显著差异。
该临床试验结果表明，在三周时间内，与三氯生/氟化钠/共聚物（高露洁全效）相比，使用0.45%氟化亚锡凝胶可显著抑制牙龈炎的发生。然而，在没有定期口腔卫生措施的情况下，氟化亚锡和三氯生/氟化钠/共聚物（高露洁全效）均没有足够的抗菌活性来抑制牙菌斑的形成。
