Bunker Matthew, Davies Martyn, Roberts Clive
The University of Nottingham, Laboratory of Biophysics and Surface Analysis, University Park, UK.
Expert Opin Drug Deliv. 2005 Jul;2(4):613-24. doi: 10.1517/17425247.2.4.613.
This review charts the progress of atomic force microscopy (AFM) to investigate particle interactions relevant to the performance of inhalers. AFM provides a unique opportunity to examine and quantify single particle behaviour of powdered drugs and excipients in a variety of environmental conditions. An introduction to AFM and particle interactions is given. Comparative experiments that rank adhesion between materials, and quantitative experiments that lead to the measurement of properties such as the work of adhesion and surface energy, are reviewed. The AFM has been widely used to investigate the effects of relative humidity and surface roughness on particle adhesion; these experiments are also reviewed. In the final section, the potential of this approach to screen formulations is discussed.
本综述阐述了原子力显微镜（AFM）在研究与吸入器性能相关的颗粒相互作用方面的进展。AFM为在各种环境条件下检查和量化粉末状药物及辅料的单颗粒行为提供了独特的机会。本文介绍了AFM及颗粒相互作用。综述了对材料间粘附性进行排序的对比实验以及用于测量粘附功和表面能等性质的定量实验。AFM已被广泛用于研究相对湿度和表面粗糙度对颗粒粘附的影响；这些实验也在本文中进行了综述。在最后一部分，讨论了这种方法用于筛选制剂的潜力。
