Lohrmann Maike, Kappl Michael, Butt Hans-Juergen, Urbanetz Nora Anne, Lippold Bernhard Christian
Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
Eur J Pharm Biopharm. 2007 Sep;67(2):579-86. doi: 10.1016/j.ejpb.2007.02.011. Epub 2007 Feb 22.
Dry powder inhalers mostly contain carrier based formulations where micronized drug particles are adhered to coarse carrier particles. The performance of the dry powder inhaler depends on the inhaler device, the inhalation manoeuvre and the formulation. The most important factor influencing the behaviour of the formulation is the adhesion force acting between the active ingredient and the carrier particles, which can be measured using different methods, for example the centrifuge technique or atomic force microscopy. In this study the tensile strength method, usually applied to determine cohesion forces between powder particles of one material, is optimized for adhesion force measurements between powder particles of unlike materials. Adhesion force measurements between the carrier materials lactose or mannitol and the drug substance salbutamol sulphate using the tensile strength method and the atomic force microscopy show higher values with increasing relative humidity. Consequently, the fine particle fraction determined using the Next Generation Impactor decreases with increasing relative humidity as a result of the enhanced interparticle interactions.
干粉吸入器大多含有基于载体的制剂，其中微粉化的药物颗粒附着在粗载体颗粒上。干粉吸入器的性能取决于吸入器装置、吸入动作和制剂。影响制剂行为的最重要因素是活性成分与载体颗粒之间的粘附力，可使用不同方法进行测量，例如离心技术或原子力显微镜。在本研究中，通常用于测定一种材料粉末颗粒之间内聚力的拉伸强度法，针对不同材料粉末颗粒之间的粘附力测量进行了优化。使用拉伸强度法和原子力显微镜对载体材料乳糖或甘露醇与药物硫酸沙丁胺醇之间的粘附力进行测量，结果表明随着相对湿度的增加，粘附力值升高。因此，由于颗粒间相互作用增强，使用下一代撞击器测定的细颗粒分数随相对湿度增加而降低。
