Im Dong-Soon
Laboratory of Pharmacology and Research Institute of Drug Development, College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
Acta Pharmacol Sin. 2005 Dec;26(12):1435-41. doi: 10.1111/j.1745-7254.2005.00237.x.
Recently, two different chemicals have been matched as ligands with the same G-protein-coupled receptor (GPCR). Double-pairing of OGR1 family GPCRs with proton and lysolipid raises several questions. First, whether both are the real ligands for the GPCRs. Second, whether modulation of a GPCR by two chemicals could be possible. Third, one of the chemicals is proton. Proton-sensing not only is a new action mode of GPCR activation, but also it could be generalized in other GPCRs. In this review, I would like to summarize the issue and discuss questions with pharmacological criteria.
最近，两种不同的化学物质被确定为与同一G蛋白偶联受体（GPCR）相结合的配体。OGR1家族GPCR与质子和溶血脂质的双重配对引发了几个问题。第一，这两种物质是否都是该GPCR的真正配体。第二，一种GPCR是否有可能被两种化学物质调节。第三，其中一种化学物质是质子。质子感应不仅是GPCR激活的一种新作用模式，而且可能在其他GPCR中普遍存在。在这篇综述中，我将总结这个问题，并根据药理学标准讨论相关问题。
