Palmio Johanna, Huuhka Martti, Saransaari Pirjo, Oja Simo S, Peltola Jukka, Leinonen Esa, Suhonen Jaana, Keränen Tapani
Department of Neurology, University of Tampere, and Department of Neurology, Tampere University Hospital, Tampere, Finland.
Psychiatry Res. 2005 Dec 15;137(3):183-90. doi: 10.1016/j.psychres.2005.07.010. Epub 2005 Nov 17.
There are indications that mood disorders may be related to perturbations in the amino acid transmitters. The amino acids may thus be targets of treatment of depression. The purpose of this pilot study was to measure the acute effects of a single administration of electroconvulsive therapy (ECT) on the plasma levels of amino acids in depressed patients. ECT was administered to 10 patients with major depressive disorder. Altogether 23 plasma amino acids were analyzed before and at 2, 6, 24 and 48 h after ECT. The levels of glutamate and aspartate increased at 6 h after ECT compared with the baseline. Also the levels of total tryptophan increased 2-24 h after ECT. There were also elevations in other amino acids at 6 and 24 h. The levels of gamma-aminobutyric acid (GABA) decreased at 2 h. In this study the acute effects of single ECT were associated with changes in the levels of glutamate, aspartate, GABA, tryptophan and some other amino acids. The preliminary data suggest that the therapeutic effects of ECT in depression may be due to mechanisms involving these amino acid transmitters.
有迹象表明，情绪障碍可能与氨基酸递质的紊乱有关。因此，氨基酸可能成为治疗抑郁症的靶点。本初步研究的目的是测量单次电休克治疗（ECT）对抑郁症患者血浆氨基酸水平的急性影响。对10例重度抑郁症患者实施了ECT治疗。在ECT治疗前以及治疗后2小时、6小时、24小时和48小时，共分析了23种血浆氨基酸。与基线相比，ECT治疗后6小时谷氨酸和天冬氨酸水平升高。ECT治疗后2至24小时总色氨酸水平也升高。在6小时和24小时时其他氨基酸水平也有所升高。γ-氨基丁酸（GABA）水平在2小时时下降。在本研究中，单次ECT的急性效应与谷氨酸、天冬氨酸、GABA、色氨酸和其他一些氨基酸水平的变化有关。初步数据表明，ECT治疗抑郁症的疗效可能归因于涉及这些氨基酸递质的机制。
