Bocchio-Chiavetto Luisella, Zanardini Roberta, Bortolomasi Marco, Abate Maria, Segala Matilde, Giacopuzzi Mario, Riva Marco Andrea, Marchina Eleonora, Pasqualetti Patrizio, Perez Jorge, Gennarelli Massimo
Genetics Unit, IRCCS Centro S. Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25123 Brescia, Italy.
Eur Neuropsychopharmacol. 2006 Dec;16(8):620-4. doi: 10.1016/j.euroneuro.2006.04.010. Epub 2006 Jun 6.
Several findings have suggested that the neurotrophin BDNF could contribute to clinical efficacy of antidepressant treatments. The purpose of this study was to analyse if ECT operates a modulation of serum BDNF levels in a sample of drug resistant depressed patients. The results obtained show significantly higher serum levels of BDNF following ECT. More specifically, while no change occurred in the whole sample between T0 (baseline) and T1 (after ECT) (p=0.543) a significant increase has been identified at T2, one month after the end of ECT (p=0.002). However, the BDNF augmentation was evident even between T0 and T1 in a subgroup of patients who has low baseline BDNF levels. Although future researches are needed, the results herein presented show for the first time that ECT is associated with changes in serum BDNF and further support the possible involvement of BDNF in antidepressant therapies.
多项研究结果表明，神经营养因子脑源性神经营因子（BDNF）可能有助于抗抑郁治疗的临床疗效。本研究的目的是分析在一组耐药性抑郁症患者样本中，电休克治疗（ECT）是否会对血清BDNF水平产生调节作用。所得结果显示，ECT后血清BDNF水平显著升高。更具体地说，虽然在整个样本中，T0（基线）和T1（ECT后）之间没有变化（p = 0.543），但在ECT结束后一个月的T2时发现有显著增加（p = 0.002）。然而，在基线BDNF水平较低的患者亚组中，T0和T1之间BDNF的增加也很明显。尽管还需要进一步的研究，但本文所呈现的结果首次表明，ECT与血清BDNF的变化有关，并进一步支持了BDNF可能参与抗抑郁治疗的观点。
