Eaton K A, Morgan D R, Krakowka S
Department of Veterinary Pathobiology, College of Veterinary Medicine, Ohio State University, Columbus 43210.
J Med Microbiol. 1992 Aug;37(2):123-7. doi: 10.1099/00222615-37-2-123.
Non-motile variants of Helicobacter pylori (strain 26695) occurred with a frequency of 1.6 (SD 0.4) x 10(-4) variants/cell/division cycle, and reversion to the motile form occurred with a frequency of less than 10(-7) variants/cell/division cycle. The two forms remained greater than 90% pure for up to 50 cell divisions and differed only in the presence or absence of motility and flagella. Bacteria were recovered from nine of 10 gnotobiotic piglets inoculated orally with motile H. pylori, but from only two of eight inoculated with the non-motile variant. The motile form survived for 21 days in infected piglets, but the non-motile variant survived for only 6 days. Bacteria recovered from piglets inoculated with the non-motile variant were non-motile. These data support the hypothesis that motility is a colonisation factor for H. pylori.
幽门螺杆菌（菌株26695）的非运动型变体出现频率为1.6（标准差0.4）×10⁻⁴个变体/细胞/分裂周期，而回复为运动型的频率低于10⁻⁷个变体/细胞/分裂周期。这两种形态在多达50个细胞分裂过程中纯度均保持高于90%，仅在是否具有运动性和鞭毛方面存在差异。用运动型幽门螺杆菌经口接种的10只无菌仔猪中有9只检测到细菌，但接种非运动型变体的8只仔猪中只有2只检测到细菌。运动型在感染仔猪中存活21天，而非运动型变体仅存活6天。从接种非运动型变体的仔猪中分离出的细菌为非运动型。这些数据支持运动性是幽门螺杆菌的定植因子这一假说。
