Ellinas P A, Rosner F
Department of Medicine, Queens Hospital Center, New York.
J Natl Med Assoc. 1992 Jul;84(7):617-24.
This article reports the results of a retrospective study of 11 patients with rhabdomyolysis-induced acute renal failure. All patients had multiple risk factors for rhabdomyolysis, the most common of which were alcoholism, illicit drug abuse, compression, and trauma. Patients with combined alcohol/illicit drug abuse had more severe electrolyte imbalances than patients without alcohol/illicit drug abuse. Myoglobinuria was detected in only half the patients despite rhabdomyolysis and urine "hematest" positivity. The serum creatine phosphokinase level was elevated in all of the patients, which is a good marker for rhabdomyolysis. Rhabdomyolysis is a relatively common disorder in municipal hospitals. Routine serum creatine phosphokinase levels should be checked on patients at risk, especially alcoholics, illicit drug abusers, and older patients.
本文报告了一项对11例横纹肌溶解症所致急性肾衰竭患者的回顾性研究结果。所有患者均有多个横纹肌溶解症的危险因素,其中最常见的是酗酒、非法药物滥用、挤压和创伤。合并酗酒/非法药物滥用的患者比未合并酗酒/非法药物滥用的患者有更严重的电解质失衡。尽管存在横纹肌溶解症且尿“潜血试验”呈阳性,但仅半数患者检测到肌红蛋白尿。所有患者的血清肌酸磷酸激酶水平均升高,这是横纹肌溶解症的一个良好标志物。横纹肌溶解症在市立医院是一种相对常见的疾病。对于有风险的患者,尤其是酗酒者、非法药物滥用者和老年患者,应常规检查血清肌酸磷酸激酶水平。