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本文引用的文献

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Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells.小鼠小肠上皮内淋巴细胞、派尔集合淋巴结和固有层细胞的分离。
Curr Protoc Immunol. 2001 May;Chapter 3:Unit 3.19. doi: 10.1002/0471142735.im0319s17.
2
Induction of a rapid and strong antigen-specific intraepithelial lymphocyte response during oral Encephalitozoon cuniculi infection.口服兔脑炎微孢子虫感染期间快速且强烈的抗原特异性上皮内淋巴细胞反应的诱导。
J Immunol. 2004 Apr 1;172(7):4402-9. doi: 10.4049/jimmunol.172.7.4402.
3
Role of murine intestinal intraepithelial lymphocytes and lamina propria lymphocytes against primary and challenge infections with Cryptosporidium parvum.小鼠肠道上皮内淋巴细胞和固有层淋巴细胞在抵抗微小隐孢子虫原发性感染和再次感染中的作用。
J Parasitol. 2003 Apr;89(2):270-5. doi: 10.1645/0022-3395(2003)089[0270:ROMIIL]2.0.CO;2.
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CD8 T cell responses to infectious pathogens.CD8 T细胞对传染性病原体的反应。
Annu Rev Immunol. 2003;21:29-70. doi: 10.1146/annurev.immunol.21.120601.141114. Epub 2001 Dec 19.
5
Most murine CD8+ intestinal intraepithelial lymphocytes are partially but not fully activated T cells.大多数小鼠CD8 +肠道上皮内淋巴细胞是部分而非完全活化的T细胞。
J Immunol. 2002 Nov 1;169(9):4717-22. doi: 10.4049/jimmunol.169.9.4717.
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Contribution of CD8+ T cells to innate immunity: IFN-gamma secretion induced by IL-12 and IL-18.CD8 + T细胞对固有免疫的贡献：IL - 12和IL - 18诱导的γ干扰素分泌
Eur J Immunol. 2002 Oct;32(10):2807-16. doi: 10.1002/1521-4141(2002010)32:10<2807::AID-IMMU2807>3.0.CO;2-0.
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Intraepithelial lymphocytes: exploring the Third Way in immunology.上皮内淋巴细胞：探索免疫学的第三条道路。
Nat Immunol. 2001 Nov;2(11):997-1003. doi: 10.1038/ni1101-997.
8
Cytotoxic T cells in AIDS colonic cryptosporidiosis.艾滋病合并结肠隐孢子虫病中的细胞毒性T细胞
J Clin Pathol. 2001 Apr;54(4):298-303. doi: 10.1136/jcp.54.4.298.
9
Rapid increase of mucosal CD4 T cells followed by clearance of intestinal cryptosporidiosis in an AIDS patient receiving highly active antiretroviral therapy.在一名接受高效抗逆转录病毒治疗的艾滋病患者中，黏膜CD4 T细胞迅速增加，随后肠道隐孢子虫病得以清除。
Gastroenterology. 2001 Mar;120(4):984-7. doi: 10.1053/gast.2001.22557.
10
Evidence for the emergence of a type-1-like immune response in intestinal mucosa of calves recovering from cryptosporidiosis.隐孢子虫病康复期犊牛肠道黏膜中出现类似1型免疫反应的证据。
J Parasitol. 2001 Feb;87(1):90-5. doi: 10.1645/0022-3395(2001)087[0090:EFTEOA]2.0.CO;2.

γ干扰素的早期肠道黏膜来源与小鼠对微小隐孢子虫感染的抗性及控制有关。

An early intestinal mucosal source of gamma interferon is associated with resistance to and control of Cryptosporidium parvum infection in mice.

作者信息

Leav Brett A, Yoshida Masaru, Rogers Kathleen, Cohen Seth, Godiwala Nihal, Blumberg Richard S, Ward Honorine

机构信息

Division of Geographic Medicine and Infectious Diseases, Tufts-New England Medical Center, Box 041, 750 Washington Street, Boston, MA 02111, USA.

出版信息

Infect Immun. 2005 Dec;73(12):8425-8. doi: 10.1128/IAI.73.12.8425-8428.2005.

DOI:10.1128/IAI.73.12.8425-8428.2005
PMID:16299343
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1307021/
Abstract

Resistance to and control of Cryptosporidium parvum infection in mice in the absence of adaptive immunity appears to be gamma interferon (IFN-gamma) dependent. Using an IFN-gamma-neutralizing antibody in a murine model, we demonstrated increased susceptibility to infection within 24 h. We correlated this early resistance and control with increased mucosal expression of IFN-gamma and demonstrate that CD8+ T-cell receptor alphabeta intestinal intraepithelial lymphocytes express and secrete this cytokine shortly after infection. The rapid kinetics of IFN-gamma expression and secretion by naive CD8+ T cells in response to a protozoan pathogen have not previously been demonstrated.

摘要

在缺乏适应性免疫的情况下，小鼠对微小隐孢子虫感染的抵抗力和控制似乎依赖于γ干扰素（IFN-γ）。在小鼠模型中使用IFN-γ中和抗体，我们证明在24小时内对感染的易感性增加。我们将这种早期抵抗力和控制与IFN-γ黏膜表达增加相关联，并证明CD8⁺T细胞受体αβ肠上皮内淋巴细胞在感染后不久表达并分泌这种细胞因子。以前尚未证明幼稚CD8⁺T细胞对原生动物病原体反应时IFN-γ表达和分泌的快速动力学。