在实验性彭亨布鲁线虫感染中，嗜酸性粒细胞而非嗜酸性粒细胞过氧化物酶或主要碱性蛋白对宿主保护很重要。
Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infection.
作者信息
Ramalingam Thirumalai, Porte Patricia, Lee James, Rajan T V
机构信息
Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3105, USA.
出版信息
Infect Immun. 2005 Dec;73(12):8442-3. doi: 10.1128/IAI.73.12.8442-8443.2005.
Abstract
The attenuation of eosinophilia by the administration of monoclonal antibodies to CCR3 consistently correlates with impairment in worm elimination following primary intraperitoneal Brugia pahangi infections in mice. Host protection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophils are essential in host protection but that neither EPO nor MBP-1 alone is.
摘要
给予抗CCR3单克隆抗体后嗜酸性粒细胞增多症的减轻，始终与小鼠初次腹腔感染彭亨布鲁线虫后蠕虫清除受损相关。在缺乏嗜酸性粒细胞过氧化物酶（EPO）或主要碱性蛋白1（MBP-1）的小鼠中，宿主保护功能未受损，这表明嗜酸性粒细胞在宿主保护中至关重要，但单独的EPO或MBP-1并非如此。
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