Plagnol Vincent, Padhukasahasram Badri, Wall Jeffrey D, Marjoram Paul, Nordborg Magnus
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-2910, USA.
Genetics. 2006 Apr;172(4):2441-8. doi: 10.1534/genetics.104.040311. Epub 2005 Nov 19.
In this article we infer the rates of gene conversion and crossing over in Arabidopsis thaliana from population genetic data. Our data set is a genomewide survey consisting of 1347 fragments of length 600 bp sequenced in 96 accessions. It has several orders of magnitude more markers than any previous nonhuman study. This allows for more accurate inference as well as a detailed comparison between theoretical expectations and observations. Our methodology is specifically set to account for deviations such as recurrent mutations or a skewed frequency spectrum. We found that even if some components of the model clearly do not fit, the pattern of LD conforms to theoretical expectations quite well. The ratio of gene conversion to crossing over is estimated to be around one. We also find evidence for fine-scale variations of the crossing-over rate.
在本文中，我们从群体遗传数据推断拟南芥中的基因转换率和交叉率。我们的数据集是一项全基因组调查，由96个种质中测序的1347个长度为600 bp的片段组成。它比以往任何非人类研究拥有多几个数量级的标记。这使得推断更准确，也能对理论预期和观察结果进行详细比较。我们的方法专门用于考虑诸如反复突变或偏态频谱等偏差。我们发现，即使模型的某些组成部分明显不拟合，连锁不平衡模式也与理论预期相当吻合。基因转换与交叉的比率估计约为1。我们还发现了交叉率存在精细尺度变化的证据。
