包膜糖蛋白与Vpu促进的1型人类免疫缺陷病毒衣壳输出的CD4非依赖性
Envelope glycoprotein and CD4 independence of vpu-facilitated human immunodeficiency virus type 1 capsid export.
作者信息
Yao X J, Göttlinger H, Haseltine W A, Cohen E A
机构信息
Département de Microbiologie et Immunologie, Faculté de Médecine, Université de Montréal, Québec, Canada.
出版信息
J Virol. 1992 Aug;66(8):5119-26. doi: 10.1128/JVI.66.8.5119-5126.1992.
Abstract
The effect of vpu on the release of human immunodeficiency type 1 capsid proteins was examined in the presence or absence of virus-encoded envelope glycoproteins as well as in cells which constitutively express either the CD4 or CD8 protein. The results show that vpu-mediated facilitated export of capsid proteins from HeLa cells does not require expression of the envelope glycoprotein. The experiments also show that export of virus capsid proteins from HeLa cells facilitated by vpu is not affected by coexpression of either the CD4 or CD8 protein. The vpu protein acts in trans to facilitate export of virus capsid proteins from HeLa cells.
摘要
在有或没有病毒编码的包膜糖蛋白存在的情况下，以及在组成性表达CD4或CD8蛋白的细胞中，研究了Vpu对1型人类免疫缺陷病毒衣壳蛋白释放的影响。结果表明，Vpu介导的衣壳蛋白从HeLa细胞的易化输出不需要包膜糖蛋白的表达。实验还表明，Vpu促进的病毒衣壳蛋白从HeLa细胞的输出不受CD4或CD8蛋白共表达的影响。Vpu蛋白通过反式作用促进病毒衣壳蛋白从HeLa细胞的输出。
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