Wang Kai, Xie Shiqi, Sun Bing
Laboratory of Molecular Virology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 225 South Chongqing Road, Shanghai 200025, China.
Biochim Biophys Acta. 2011 Feb;1808(2):510-5. doi: 10.1016/j.bbamem.2010.05.006. Epub 2010 May 15.
Viral ion channels are short membrane proteins with 50-120 amino acids and play an important role either in regulating virus replication, such as virus entry, assembly and release or modulating the electrochemical balance in the subcellular compartments of host cells. This review summarizes the recent advances in viral encoded ion channel proteins (or viroporins), including PBCV-1 KcV, influenza M2, HIV-1 Vpu, HCV p7, picornavirus 2B, and coronavirus E and 3a. We focus on their function and mechanisms, and also discuss viral ion channel protein serving as a potential drug target.
病毒离子通道是由50 - 120个氨基酸组成的短膜蛋白，在调节病毒复制（如病毒进入、组装和释放）或调节宿主细胞亚细胞区室中的电化学平衡方面发挥重要作用。本综述总结了病毒编码离子通道蛋白（或病毒孔蛋白）的最新进展，包括绿藻病毒PBCV - 1 KcV、流感病毒M2、HIV - 1 Vpu、丙型肝炎病毒p7、微小核糖核酸病毒2B以及冠状病毒E和3a。我们重点关注它们的功能和机制，同时也讨论病毒离子通道蛋白作为潜在药物靶点的情况。
