Napier Richard M
Warwick HRI, University of Warwick, Wellesbourne, Warwick, CV35 9EF, UK.
Bioessays. 2005 Dec;27(12):1213-7. doi: 10.1002/bies.20329.
Back-to-back papers have described the identification of a family of receptors for the plant hormone auxin. Most developmental processes in plants are dependent on auxin signalling making this discovery a landmark in the search for the mechanism of auxin action. The TIR1 gene translates into a protein with recognised motifs including an F-box domain and TIR1 forms part of an important ubiquitination complex that tags other proteins for degradation. Specific amongst the targets of TIR1 are a set of auxin-regulated transcription factors. The latest work has shown that TIR1 itself is also the binding site for auxin making it an auxin receptor with no requirement for a biochemical signalling cascade.
相继发表的两篇论文描述了植物激素生长素受体家族的鉴定。植物中的大多数发育过程都依赖于生长素信号传导，这一发现是寻找生长素作用机制过程中的一个里程碑。TIR1基因翻译出的蛋白质具有包括F-box结构域在内的公认基序，并且TIR1是一个重要的泛素化复合体的一部分，该复合体标记其他蛋白质以便降解。TIR1的特定靶标是一组生长素调节的转录因子。最新研究表明，TIR1本身也是生长素的结合位点，使其成为一种无需生化信号级联反应的生长素受体。
