Hoffmann B, Kokott A, Shafranska O, Detsch R, Winter S, Eisenbarth E, Peters K, Breme J, Kirkpatrick C J, Ziegler G
Friedrich-Baur-Forschungsinstitut für Biomaterialien, Universität Bayreuth, Ludwig-Thoma-Str. 36c, 95440 Bayreuth.
Biomed Tech (Berl). 2005 Oct;50(10):320-9. doi: 10.1515/BMT.2005.045.
Alloys based on titanium or cobalt have been used as implant materials for decades with good success. Because of their natural oxide layer these alloys reveal good corrosion behaviour. In contact with physiological solution metal release takes place, which can cause inflammation. Coatings can improve the corrosion behaviour. In this study Ti6Al4V and Co28Cr6Mo alloys, which are frequently used as implant materials, were tested. Polished discs of these alloys and polished discs, which were coated with TiO2-layers by sol-gel chemistry, were compared regarding their corrosion behaviour and metal ion releasing. The releasing of Al, V, Ti, Co, Cr and Mo was quantified by ICP-MS analysis. The TiO2-coating reduced the release of all ions except of the Al-ion. Both alloys showed a deviating kinetic of ion releasing. In addition, cell response (cell vitality, cell proliferation, endothelial marker CD31 and actin allocation) of osteoblasts and endothelial cells were investigated.
基于钛或钴的合金作为植入材料已经使用了几十年，取得了良好的效果。由于其天然氧化层，这些合金具有良好的耐腐蚀性能。与生理溶液接触时会发生金属释放，这可能会引起炎症。涂层可以改善耐腐蚀性能。在本研究中，测试了常用作植入材料的Ti6Al4V和Co28Cr6Mo合金。比较了这些合金的抛光圆盘以及通过溶胶 - 凝胶化学涂覆有TiO2层的抛光圆盘的耐腐蚀性能和金属离子释放情况。通过ICP-MS分析对Al、V、Ti、Co、Cr和Mo的释放进行了定量。TiO2涂层减少了除Al离子外所有离子的释放。两种合金都表现出不同的离子释放动力学。此外，还研究了成骨细胞和内皮细胞的细胞反应（细胞活力、细胞增殖、内皮标志物CD31和肌动蛋白分布）。
