Sánchez J, Buendía A J, Vilafranca M, Velarde R, Altimara J, Martínez C M, Navarro J A
Departamento de Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad de Murcia, 30100 Murcia, Spain.
Vet Pathol. 2005 Nov;42(6):828-33. doi: 10.1354/vp.42-6-828.
Four cases of neoplasms in the heads of old dogs were studied. All the dogs showed both carcinomatous and sarcomatous malignant components in an admixed growing pattern. Histologic analysis of the tumors showed that the carcinomatous cells resembled squamous cell carcinoma in all dogs except one, where an adenoid arrangement of the neoplastic cells was also observed. The sarcomatous component showed osteoid matrix produced by pleomorphic poorly differentiated cells, which is regarded as a typical feature of osteosarcomas. Immunohistochemical analysis demonstrated that the components were positive only for cytokeratin (carcinomatous component) or vimentin (sarcomatous component). This observation led us to classify the neoplasms as true carcinosarcomas, thus providing evidence of a new preferential location for this unusual tumor in dog.
对4例老年犬头部肿瘤进行了研究。所有犬的肿瘤均呈现癌性和肉瘤性恶性成分混合生长模式。肿瘤的组织学分析显示，除1例犬外，其余犬的癌细胞均类似鳞状细胞癌，在该例中还观察到肿瘤细胞呈腺样排列。肉瘤成分显示由多形性低分化细胞产生的类骨质基质，这被认为是骨肉瘤的典型特征。免疫组织化学分析表明，这些成分仅对细胞角蛋白（癌性成分）或波形蛋白（肉瘤性成分）呈阳性。这一观察结果使我们将这些肿瘤归类为真性癌肉瘤，从而为这种不寻常的肿瘤在犬中的新的偏好位置提供了证据。
