Rissi D R
Department of Pathology and Athens Veterinary Diagnostic Laboratory, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.
J Comp Pathol. 2019 Jul;170:22-25. doi: 10.1016/j.jcpa.2019.05.003. Epub 2019 Jun 12.
Malignant pilomatricomas are uncommon cutaneous neoplasms in veterinary and human medicine. Pilomatrical carcinosarcoma is a rare subset of malignant pilomatricoma that has been described in man. This article reports a neoplasm with morphological features of pilomatrical carcinosarcoma in a dog. The nodular neoplasm occurred on the left lateral hock and was partially alopecic. Microscopically, the tumour was composed of a cystic carcinomatous component surrounding areas of abrupt keratinization and a sarcomatous component exhibiting bundles of spindle cells and irregular, scalloped areas of mineralized and non-mineralized osteoid matrix. The carcinomatous and sarcomatous areas were immunoreactive for pan-cytokeratin and vimentin, respectively, while immunoreactivity for e-cadherin was restricted to the carcinomatous component of the neoplasm. The unique morphological features of this tumour were similar to those described in human pilomatrical carcinosarcoma.
恶性毛母质瘤在兽医和人类医学中都是不常见的皮肤肿瘤。毛母质癌肉瘤是恶性毛母质瘤中一种罕见的亚型，已在人类中有过描述。本文报告了一只患有具有毛母质癌肉瘤形态特征肿瘤的犬。该结节状肿瘤发生于左外侧跗关节处，局部脱毛。显微镜下，肿瘤由围绕突然角化区域的囊性癌成分和表现为梭形细胞束以及矿化和非矿化类骨质基质不规则、扇形区域的肉瘤成分组成。癌性和肉瘤性区域分别对泛细胞角蛋白和波形蛋白呈免疫反应，而E-钙黏蛋白的免疫反应仅限于肿瘤的癌性成分。该肿瘤独特的形态特征与人类毛母质癌肉瘤中所描述的相似。
