Berrocal A, Montgomery D L, Mackie J T, Storts R W
Dept. of Veterinary, Laramie, WY 82070, USA.
Vet Pathol. 2005 Nov;42(6):834-6. doi: 10.1354/vp.42-6-834.
A variety of embryonal tumors of the central nervous system, typically malignant and occurring in young individuals, are recognized in humans and animals. This report describes an invasive subdural but predominantly extramedullary primitive neuroectodermal tumor developing at the lumbosacral junction in a 6-month-old Brahman crossbred calf. The tumor was composed of spindloid embryonal cells organized in interlacing fascicles. The cells had oval to elongate or round hyperchromic nuclei, single to double nucleoli, and scant discernible cytoplasm. Immunohistochemical staining for neuron-specific enolase, synaptophysin, and S-100 protein and formation of pseudorosettes suggested neuronal and possibly ependymal differentiation.
在人类和动物中，已确认存在多种中枢神经系统胚胎性肿瘤，这些肿瘤通常具有恶性，且多发生于年轻人。本报告描述了一例侵袭性硬脑膜下但主要为髓外的原始神经外胚层肿瘤，该肿瘤发生于一头6个月大的婆罗门杂交犊牛的腰骶部交界处。肿瘤由呈交错束状排列的梭形胚胎细胞组成。细胞具有椭圆形至细长形或圆形的深染细胞核、单个至双个核仁，以及难以辨认的少量细胞质。神经元特异性烯醇化酶、突触素和S-100蛋白的免疫组织化学染色以及假菊形团的形成提示有神经元及可能的室管膜分化。
