Junginger J, Röthlisberger A, Lehmbecker A, Stein V M, Ludwig D C, Baumgärtner W, Seehusen F
Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany.
J Comp Pathol. 2013 Nov;149(4):424-8. doi: 10.1016/j.jcpa.2013.03.010. Epub 2013 May 25.
A 1-year-old German shepherd dog was presented with paraparesis quickly progressing to paraplegia. Magnetic resonance imaging revealed a large mass beneath the thoracolumbar vertebral column infiltrating the spinal canal and resulting in severe extradural compression of the spinal cord. Microscopically, this comprised a cell-rich unencapsulated tumour supported by fine bands of a fibrovascular stroma and occasionally forming primitive rosettes. Immunohistochemistry showed the tumour cells to express synaptophysin and neuron-specific enolase. Ultrastructurally, the neoplastic cells had low to moderate numbers of intracytoplasmic neurosecretory granules. A peripheral primitive neuroectodermal tumour was diagnosed. This is a rare embryonal tumour of neural origin that may have arisen from adrenal medulla, autonomic ganglia or peripheral nerves.
一只1岁的德国牧羊犬出现双下肢轻瘫，并迅速发展为截瘫。磁共振成像显示胸腰椎椎体下方有一个大肿块，浸润椎管，导致脊髓严重硬膜外受压。显微镜下，这是一个富含细胞的无包膜肿瘤，由纤维血管基质的细带支撑，偶尔形成原始菊形团。免疫组织化学显示肿瘤细胞表达突触素和神经元特异性烯醇化酶。超微结构上，肿瘤细胞的胞质内神经分泌颗粒数量少至中等。诊断为外周原始神经外胚层肿瘤。这是一种罕见的神经源性胚胎肿瘤，可能起源于肾上腺髓质、自主神经节或周围神经。
