Vincent H K, Taylor A G
The Center for the Study of Complementary and Alternative Therapies, CSCAT, University of Virginia, Charlottesville, 22908-0905, USA.
Int J Obes (Lond). 2006 Mar;30(3):400-18. doi: 10.1038/sj.ijo.0803177.
Oxidative stress may be the unifying mechanism underlying the development of comorbidities in obesity. Evidence suggests that a clustering of sources of oxidative stress exists in obesity: hyperglycemia, hyperleptinemia, increased tissue lipid levels, inadequate antioxidant defenses, increased rates of free radical formation, enzymatic sources within the endothelium, and chronic inflammation.
This review provides a summary of the available evidence on systemic oxidative stress in humans and specific metabolic pathways by which obesity may elevate systemic oxidant stress. The authors suggest possible methods of reducing oxidative stress such as antioxidant supplementation, caloric restriction and/or physical activity and surgical intervention to combat free radicals and reduce adipose tissue.
Obesity is associated with oxidative stress and can be reduced with weight loss (regardless of exercise or surgery induced weight loss), caloric restriction or antioxidant rich diets.
Oxidative stress levels are elevated in human obesity, and these levels are modifiable with various lifestyle modifications and surgical interventions.
氧化应激可能是肥胖症中共存疾病发生发展的统一机制。有证据表明，肥胖症中存在多种氧化应激源的聚集：高血糖、高瘦素血症、组织脂质水平升高、抗氧化防御不足、自由基形成速率增加、内皮中的酶源以及慢性炎症。
本综述总结了关于人类全身性氧化应激以及肥胖症可能升高全身性氧化应激的特定代谢途径的现有证据。作者提出了降低氧化应激的可能方法，如补充抗氧化剂、热量限制和/或体育活动以及手术干预，以对抗自由基并减少脂肪组织。
肥胖症与氧化应激相关，并且可以通过减肥（无论运动或手术引起的体重减轻）、热量限制或富含抗氧化剂的饮食来降低。
人类肥胖症中氧化应激水平升高，并且这些水平可通过各种生活方式改变和手术干预来调节。
