Valdecantos María Pilar, Pérez-Matute Patricia, Martínez José Alfredo
Departamento de Ciencias de la Alimentación, Fisiología y Toxicología, Universidad de Navarra.
Rev Invest Clin. 2009 Mar-Apr;61(2):127-39.
The prevalence of obesity has significantly increased during the last decades reaching epidemic proportions in many countries. Obesity has been described as a state of chronic oxidative stress. Furthermore, oxidative stress has been defined as the link between obesity and its major associated disorders such as insulin resistance, hypertension, etc. Because of this, recent studies have suggested the potential therapeutic role of dietary antioxidant supplementation in the reduction of body weight or its beneficial effect on several obesity related disorders. This review updates the data described during the last years (2002-2008) regarding the relationship between obesity and oxidative stress as well as the role of dietary antioxidant supplementation in the reduction of oxidative stress, obesity and its principal associated comorbidities. Despite the available data, here summarized, further studies are needed in order to deeply understand the molecular mechanisms involved in the beneficial effects of dietary antioxidants on obesity and associated disorders.
在过去几十年间，肥胖症的患病率显著上升，在许多国家已达到流行程度。肥胖被描述为一种慢性氧化应激状态。此外，氧化应激被定义为肥胖与其主要相关疾病（如胰岛素抵抗、高血压等）之间的联系。因此，最近的研究表明，膳食补充抗氧化剂在减轻体重或对几种与肥胖相关的疾病产生有益影响方面具有潜在的治疗作用。这篇综述更新了过去几年（2002 - 2008年）所描述的有关肥胖与氧化应激之间的关系，以及膳食补充抗氧化剂在减轻氧化应激、肥胖及其主要相关合并症方面的作用的数据。尽管有本文总结的现有数据，但仍需要进一步研究，以便深入了解膳食抗氧化剂对肥胖及相关疾病产生有益影响所涉及的分子机制。
