Lorenzen J, Wedel A K, Lisboa B W, Löning T, Adam G
Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Hamburg-Eppendorf.
Rofo. 2005 Nov;177(11):1545-51. doi: 10.1055/s-2005-858636.
The purpose of the study was to assess the final clinical outcome of BI-RADS Categories for diagnostic mammography and sonography.
We analysed 632 mammography and sonography examinations from women with diagnostic indications (age: 23 - 100, mean 58) performed during 2001 and 2003. All patients received mammography and sonography examinations at different outside facilities and all patients received an additional sonography examination at the university radiology department and if necessary supplemental mammographic views. Final clinical outcome (Histology: 554; follow-up: 78) was ascertained in each case and concordance of BI-RADS-categories for mammography and sonography and final diagnosis were analysed.
Final diagnosis yielded 230 benign lesions (36 %) and 402 cancers (64 %). Concordance of BI-RADS Assessment and final outcome was documented in 542 cases (86 %). There were 11 correct category 1 and 2 assessments (2 %). 142 lesions were classified with BI-RADS 3 (22 %) with 5 false negative ratings. There were 264 category 4 lesions (42 %) with a PPV for a malignant lesion of 71 % (187/264) and finally 215 BI-RADS 5 lesions with a PPV of 98 % (210/215). Overall sensitivity of mammography was 92 % with specificity of 75 % and for sonography 86 % and 76 %. Mammography had a significantly higher detection rate for malignant lesions than sonography. The highest correlation between BI-RADS category and final outcome was documented for the diagnostic combination of mammography and sonography with a kappa-value of 0.817 (p < 0.001), followed by mammography (kappa: 0.684) and sonography (kappa: 0.631). The overall correlation was 0.681 (p < 0.001).
BI-RADS assessments of diagnostic mammography and sonography yields in a high cancer detection rate with a justifiable part of false positive ratings.
本研究旨在评估乳腺影像报告和数据系统(BI-RADS)分类在诊断性乳腺钼靶摄影和超声检查中的最终临床结果。
我们分析了2001年至2003年期间632例有诊断指征女性(年龄23 - 100岁,平均58岁)的乳腺钼靶摄影和超声检查。所有患者均在不同外部机构接受了乳腺钼靶摄影和超声检查,所有患者在大学放射科又接受了一次超声检查,必要时还进行了补充乳腺钼靶摄影。确定了每例患者的最终临床结果(组织学检查:554例;随访:78例),并分析了乳腺钼靶摄影和超声检查的BI-RADS分类与最终诊断的一致性。
最终诊断出230例良性病变(36%)和402例癌症(64%)。542例(86%)记录了BI-RADS评估与最终结果的一致性。有11例正确的1类和2类评估(2%)。142个病变被分类为BI-RADS 3类(22%),其中有5例假阴性评级。有264个4类病变(42%),恶性病变的阳性预测值为71%(187/264),最后有215个BI-RADS 5类病变,阳性预测值为98%(210/215)。乳腺钼靶摄影的总体敏感性为92%,特异性为75%,超声检查的敏感性为86%,特异性为76%。乳腺钼靶摄影对恶性病变的检出率明显高于超声检查。乳腺钼靶摄影和超声检查的诊断组合中,BI-RADS分类与最终结果的相关性最高,kappa值为0.817(p < 0.001),其次是乳腺钼靶摄影(kappa:0.684)和超声检查(kappa:0.631)。总体相关性为0.681(p < 0.001)。
乳腺钼靶摄影和超声检查的BI-RADS评估具有较高的癌症检出率,且假阳性评级在合理范围内。