Shao T C, Li H L, Kasper S, Matusik R, Ittmann M, Cunningham G R
Department of Medicine, Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston 77030, Texas, USA.
Prostate. 2006 Mar 1;66(4):369-76. doi: 10.1002/pros.20354.
7-alpha-methyl-19-nortestosterone (MENT) is being considered for androgen replacement in testosterone deficient men and as a male contraceptive. Because androgenic effects on the prostate are a major concern, we have evaluated MENT in a transgenic model of prostate cancer.
LPB-Tag mice were castrated and infused with testosterone (T; 5 or 30 microg/day) or MENT (5 or 30 microg/day) for 4 weeks. Prostate, seminal vesicle, and levator ani muscle (LAM) weights were compared.
At an equivalent dose, MENT maintained or stimulated the mean weights of these organs more than T. However, the dorsolateral prostate/LAM ratio of weights did not favor MENT, but DNA/mg tissue and Ki 67 immunostaining suggested that MENT may increase DNA less than T.
MENT is more potent than T in maintaining or stimulating prostate, seminal vesicle, and LAM. Using doses that resulted in comparable stimulation of the levator ani muscle, MENT had similar effect on prostate weight, but increased DNA/mg prostate less than T in this transgenic mouse model of prostate cancer.
7-α-甲基-19-去甲睾酮（MENT）正被考虑用于睾酮缺乏男性的雄激素替代治疗以及作为男性避孕药。由于雄激素对前列腺的影响是一个主要关注点，我们在前列腺癌转基因模型中评估了MENT。
对LPB-Tag小鼠进行去势，并给予睾酮（T；5或30微克/天）或MENT（5或30微克/天）灌注4周。比较前列腺、精囊和提肛肌（LAM）的重量。
在等效剂量下，MENT比T更能维持或刺激这些器官的平均重量。然而，背外侧前列腺/LAM重量比并不利于MENT，但DNA/毫克组织和Ki 67免疫染色表明MENT增加的DNA可能比T少。
在维持或刺激前列腺、精囊和LAM方面，MENT比T更有效。在导致提肛肌受到类似刺激的剂量下，在这个前列腺癌转基因小鼠模型中，MENT对前列腺重量有类似影响，但增加的DNA/毫克前列腺比T少。
