Kernohan Andrew F B, Spiers Angela, Sattar Naveed, Hillier Chris, Cleland Steve J, Small Michael, Lumsden Mary-Ann, McConnell John, Petrie John R
Division of Cardiovascular and Medical Sciences, University of Glasgow, 36 Church St, Glasgow, G11 6NT, UK.
Diab Vasc Dis Res. 2004 Oct;1(2):82-8. doi: 10.3132/dvdr.2004.012.
Improvement in vascular endothelial function is widley cited as a beneficial effect of hormone replacement therapy (HRT). Women with type 2 diabetes (T2DM) are at increased cardiovascular risk and have impaired endothelial function. Any benefits of HRT on endothelial function in this group are of particular interest.
We assessed effects on vascular function of oral 17beta oestradiol (1 mg) and norethisterone (0.5 mg) in postmenopausal women with T2DM.
Double-blind, randomised, placebo-controlled trial.
Twenty-eight women had pulse wave velocity (PWV) and adhesion molecules VCAM-1 and ICAM-1 assessed before and after three months' treatment. Twenty-four women also had gluteal fat biopsy for assessment of resistance vessel function (using wire myography).
HRT did not affect PWV, VCAM-1, ICAM-1 or carbachol response. Effects of L-NAME and indomethacin on carbachol sensitivity were similar in both groups.
This HRT preparation had no detectable effect on these measures of endothelial function in women with T2DM.
血管内皮功能的改善被广泛认为是激素替代疗法（HRT）的有益效果。2型糖尿病（T2DM）女性心血管风险增加且内皮功能受损。HRT对该群体内皮功能的任何益处都尤为令人关注。
我们评估了口服17β雌二醇（1毫克）和炔诺酮（0.5毫克）对绝经后T2DM女性血管功能的影响。
双盲、随机、安慰剂对照试验。
28名女性在三个月治疗前后接受脉搏波速度（PWV）以及黏附分子VCAM-1和ICAM-1的评估。24名女性还进行了臀肌脂肪活检以评估阻力血管功能（使用线肌动描记法）。
HRT未影响PWV、VCAM-1、ICAM-1或卡巴胆碱反应。两组中L-NAME和吲哚美辛对卡巴胆碱敏感性的影响相似。
这种HRT制剂对T2DM女性的这些内皮功能指标没有可检测到的影响。
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