人乳头瘤病毒检测中自我采样与医生采样的比较。

Self-sampling versus physician-sampling for human papillomavirus testing.

作者信息

Agorastos T, Dinas K, Lloveras B, Font R, Kornegay J R, Bontis J, de Sanjose S

机构信息

First University Clinic of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Hippokrateion Hospital, Thessaloniki, Greece.

出版信息

Int J STD AIDS. 2005 Nov;16(11):727-9. doi: 10.1258/095646205774763225.

DOI:10.1258/095646205774763225

PMID:16303065

Abstract

We evaluated the detection of human papillomavirus (HPV) infection using two sampling methods of cervical exfoliated cells, consisting of self-sampling of vaginal cells and cervical sampling performed by the physician. Women included were 379 patients of the general population attending outpatient clinics in Northern Greece for routine cytological cervical dysplasia screening. HPV DNA detection was similar with both sampling techniques. The HPV prevalences in self-collected samples were 4.7% and 3.7% in the physician-collected samples (P>0.05). The Kappa statistic for HPV DNA agreement between the two methods was 0.54 (95% Confidence interval = 0.33-0.75). Self-sampling of cervico-vaginal exfoliated cells could be used as an alternative option to test for HPV infection.

摘要

我们使用两种宫颈脱落细胞采样方法评估了人乳头瘤病毒（HPV）感染的检测情况，这两种方法分别是阴道细胞的自我采样和由医生进行的宫颈采样。纳入的女性为希腊北部门诊进行常规宫颈细胞学发育异常筛查的379名普通人群患者。两种采样技术检测HPV DNA的结果相似。自我采集样本中的HPV患病率为4.7%，医生采集样本中的患病率为3.7%（P>0.05）。两种方法之间HPV DNA一致性的Kappa统计量为0.54（95%置信区间=0.33-0.75）。宫颈阴道脱落细胞的自我采样可作为检测HPV感染的替代选择。