一种适用于南非青少年人乳头瘤病毒检测的可行且简便的自我采样方法。
A Viable and Simple Self-Sampling Method for Human Papillomavirus Detection among South African Adolescents.
作者信息
Adler David H, Laher Fatima, Lazarus Erica, Grzesik Katherine, Gray Glenda E, Allan Bruce, Williamson Anna-Lise
机构信息
Department of Emergency Medicine, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA.
出版信息
J Immunol Tech Infect Dis. 2013 Sep 18;2(3). doi: 10.4172/2329-9541.1000113.
BACKGROUND
Self-sampling for Human Papillomavirus (HPV) testing may offer improved patient acceptability, decreased cost, and greater practicality than clinician collection of specimens. HPV testing among adolescents is necessary to conduct vaccine surveillance and may play a role in cervical cancer screening among some populations.
METHODS
A cross-sectional prevalence study was conducted to compare the results of self-collected and clinician-collected specimens for Human papillomavirus (HPV) testing among South African adolescent females. All participants provided self-sampled vaginal swabs and underwent clinician-collection of cervical swabs for HPV DNA analysis. The level of agreement between HPV DNA results from the two specimen collection methods was measured.
RESULTS
The level of agreement between HPV DNA results from self-collected and clinician-collected specimens was high (κ=86.7; p<0.001). A high prevalence of HPV overall was found by both specimen collection methods (57%; 95% CI 0.37-0.75). Low-risk HPV (LR-HPV) types were found slightly more frequently in self-collected specimens.
CONCLUSION
There is a high level of agreement between the HPV DNA results from self-collected and clinician-collected specimens. Self-collection of specimens for HPV testing is a viable alternative among adolescents.
背景
与临床医生采集样本相比，人乳头瘤病毒（HPV）检测的自我采样可能会提高患者的接受度，降低成本，并具有更高的实用性。对青少年进行HPV检测对于开展疫苗监测是必要的，并且在某些人群的宫颈癌筛查中可能发挥作用。
方法
进行了一项横断面患病率研究，以比较南非青少年女性中自我采集和临床医生采集的样本进行人乳头瘤病毒（HPV）检测的结果。所有参与者都提供了自我采集的阴道拭子，并接受了临床医生采集的宫颈拭子用于HPV DNA分析。测量了两种样本采集方法的HPV DNA结果之间的一致性水平。
结果
自我采集和临床医生采集的样本的HPV DNA结果之间的一致性水平很高（κ=86.7；p<0.001）。两种样本采集方法均发现HPV总体患病率很高（57%；95%CI 0.37-0.75）。在自我采集的样本中，低风险HPV（LR-HPV）类型出现的频率略高。
结论
自我采集和临床医生采集的样本的HPV DNA结果之间具有高度一致性。自我采集样本进行HPV检测在青少年中是一种可行的替代方法。
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