孕酮和CA-125在预测异位妊娠和流产性宫内妊娠中的受试者工作特征及诊断价值。

Receiver operator characteristics and diagnostic value of progesterone and CA-125 in the prediction of ectopic and abortive intrauterine gestations.

作者信息

Katsikis Ilias, Rousso David, Farmakiotis Dimitrios, Kourtis Anargyros, Diamanti-Kandarakis Evanthia, Panidis Dimitrios

机构信息

Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2006 Apr 1;125(2):226-32. doi: 10.1016/j.ejogrb.2005.10.014. Epub 2005 Nov 21.

DOI:10.1016/j.ejogrb.2005.10.014

PMID:16303230

Abstract

OBJECTIVE

The study was designed to investigate the predictive value of progesterone and CA-125 in the diagnosis of ectopic pregnancy (EP) and inevitable miscarriage.

METHODS

Forty women with EP, 20 with intrauterine (IU) abortive gestation and 20 regular pregnant women (controls) were studied. IU abortive and EP were confirmed and treated by surgery. Serum progesterone and CA-125 levels were measured at the time of presentation and 24h after surgery.

RESULTS

Women with EP had significantly lower progesterone concentrations, compared to both women with IU abortive pregnancy and controls. Women with IU abortion had significantly higher CA-125 levels, compared to the other two groups. When using a progesterone concentration of less than 10.75 ng/ml as a cut-point for the diagnosis of EP, sensitivity, specificity, positive and negative predictive values were 85%. When using CA-125 concentration of more than 41.9 U/ml as a threshold for the diagnosis of IU abortive pregnancy, sensitivity was 80%, specificity 87%, the positive predictive value was 66% and the negative predictive value 93%.

CONCLUSION

The measurement of progesterone and CA-125 levels is useful in discriminating ectopic and intrauterine abortive from normal gestations.

摘要

目的

本研究旨在探讨孕酮和CA - 125在异位妊娠（EP）和难免流产诊断中的预测价值。

方法

对40例异位妊娠患者、20例宫内（IU）流产妊娠患者和20例正常孕妇（对照组）进行研究。IU流产和EP经手术确诊并治疗。在就诊时及术后24小时测量血清孕酮和CA - 125水平。

结果

与IU流产妊娠患者和对照组相比，异位妊娠患者的孕酮浓度显著降低。与其他两组相比，IU流产患者的CA - 125水平显著升高。当以孕酮浓度低于10.75 ng/ml作为EP诊断的切点时，敏感性、特异性、阳性和阴性预测值均为85%。当以CA - 125浓度高于41.9 U/ml作为IU流产妊娠诊断的阈值时，敏感性为80%，特异性为87%，阳性预测值为66%，阴性预测值为93%。