CA-125、孕酮、β-人绒毛膜促性腺激素及雌二醇在异位妊娠早期预测中的价值
The Values of CA-125, Progesterone, ß-HCG and Estradiol in the Early Prediction of Ectopic Pregnancy.
作者信息
Abdul-Hussein Meena M, Abdul-Rasheed Omar F, Al-Moayed Hala Abdul Qadir
出版信息
Oman Med J. 2012 Mar;27(2):124-8. doi: 10.5001/omj.2012.26.
OBJECTIVE
To explore the diagnostic value and measurement of serum CA-125, the single measurement of progesterone (P), ß-HCG, and estradiol (E2) in the early diagnosis of ectopic pregnancy.
METHODS
Serum levels of CA-125, progesterone, ß-HCG and estradiol were measured by Enzyme Linked Immuno Sorbent Assay (ELISA) techniques in 40 symptomatic women with ectopic pregnancy and 24 women with normal intrauterine pregnancy during gestational age of 4-10 weeks at Al-Kadhmiya Teaching Hospital, Baghdad, Iraq, between November 2010 and June 2011.
RESULTS
The mean ±SEM serum levels of CA-125, progesterone, ß-HCG, and estradiol in patients with ectopic pregnancies (16.51±2.39U/ml; 2.54±0.47ng/ml; 72.75±12.27mIU/ml; 13.4±2.14pg/ml; respectively) were significantly lower than the levels in normal intrauterine pregnancies (74.25±18.5U/ml; 28.36±3.7ng/ml; 249.54±18.0mIU/ml; 112.7±23.6pg/ml; respectively). When using a CA-125 concentration of 20.5 U/ml as a cut-off value for the diagnosis of ectopic pregnancy, sensitivity was 75.7%, specificity 100%, the positive predictive value was 100% and the negative predictive value 71.4%.
CONCLUSION
The measurement of CA-125 and progesterone levels is useful in discriminating ectopic from normal gestations.
目的
探讨血清CA - 125、孕酮（P）单项检测、β - 人绒毛膜促性腺激素（β - HCG）及雌二醇（E2）在异位妊娠早期诊断中的诊断价值及测定方法。
方法
2010年11月至2011年6月期间，在伊拉克巴格达卡迪米亚教学医院，采用酶联免疫吸附测定（ELISA）技术，对40例有症状的异位妊娠妇女和24例孕龄在4 - 10周的正常宫内妊娠妇女，测定其血清CA - 125、孕酮、β - HCG和雌二醇水平。
结果
异位妊娠患者血清CA - 125、孕酮、β - HCG和雌二醇的平均±标准误水平（分别为16.51±2.39U/ml；2.54±0.47ng/ml；72.75±12.27mIU/ml；13.4±2.14pg/ml）显著低于正常宫内妊娠患者（分别为74.25±18.5U/ml；28.36±3.7ng/ml；249.54±18.0mIU/ml；112.7±23.6pg/ml）。以CA - 125浓度20.5U/ml作为异位妊娠诊断的临界值时，敏感性为75.7%，特异性为100%，阳性预测值为100%，阴性预测值为71.4%。
结论
测定CA - 125和孕酮水平有助于鉴别异位妊娠与正常妊娠。
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