异位妊娠和不明位置妊娠的生物标志物。
Biomarkers for ectopic pregnancy and pregnancy of unknown location.
机构信息
Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
出版信息
Fertil Steril. 2013 Mar 15;99(4):1107-16. doi: 10.1016/j.fertnstert.2012.11.038. Epub 2013 Jan 3.
Abstract
Early pregnancy failure is the most common complication of pregnancy, and 1% to 2% of all pregnancies will be ectopic. As one of the leading causes of maternal morbidity and mortality, diagnosing ectopic pregnancy and determining the fate of a pregnancy of unknown location are of great clinical concern. Several serum and plasma biomarkers for ectopic pregnancy have been investigated independently and in combination. The following is a review of the state of biomarker discovery and development for ectopic pregnancy and pregnancy of unknown location.
摘要
早期妊娠失败是妊娠最常见的并发症，所有妊娠的 1%至 2%将是异位妊娠。作为导致产妇发病率和死亡率的主要原因之一，异位妊娠的诊断和确定不明位置妊娠的结局具有重要的临床意义。已经独立和联合研究了几种血清和血浆生物标志物用于异位妊娠。以下是异位妊娠和不明位置妊娠的生物标志物发现和开发的研究现状综述。
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Possible role of adrenomedullin in the pathogenesis of tubal ectopic pregnancy.肾上腺髓质素在输卵管异位妊娠发病机制中的可能作用。
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Why does the fallopian tube fail in ectopic pregnancy? The role of activins, inducible nitric oxide synthase, and MUC1 in ectopic implantation.为什么输卵管在异位妊娠中失败？激活素、诱导型一氧化氮合酶和 MUC1 在异位植入中的作用。
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Circulating microRNA miR-323-3p as a biomarker of ectopic pregnancy.循环 microRNA miR-323-3p 作为异位妊娠的生物标志物。
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Placental mRNA in maternal plasma as a predictor of ectopic pregnancy.母体血浆中的胎盘 mRNA 作为异位妊娠的预测指标。
Int J Gynaecol Obstet. 2012 May;117(2):131-3. doi: 10.1016/j.ijgo.2011.12.011. Epub 2012 Feb 17.
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Serum activin A does not predict ectopic pregnancy as a single measurement test, alone or as part of a multi-marker panel including progesterone and hCG.血清激活素 A 作为单一测量试验，无论是单独使用还是作为包括孕激素和 hCG 的多标志物检测的一部分，均不能预测异位妊娠。
Clin Chim Acta. 2012 Apr 11;413(7-8):707-11. doi: 10.1016/j.cca.2011.12.018. Epub 2012 Jan 5.
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Performance of human chorionic gonadotropin curves in women at risk for ectopic pregnancy: exceptions to the rules.人绒毛膜促性腺激素曲线在异位妊娠风险女性中的表现：规则的例外。
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