Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Fertil Steril. 2013 Mar 15;99(4):1107-16. doi: 10.1016/j.fertnstert.2012.11.038. Epub 2013 Jan 3.
Early pregnancy failure is the most common complication of pregnancy, and 1% to 2% of all pregnancies will be ectopic. As one of the leading causes of maternal morbidity and mortality, diagnosing ectopic pregnancy and determining the fate of a pregnancy of unknown location are of great clinical concern. Several serum and plasma biomarkers for ectopic pregnancy have been investigated independently and in combination. The following is a review of the state of biomarker discovery and development for ectopic pregnancy and pregnancy of unknown location.
早期妊娠失败是妊娠最常见的并发症，所有妊娠的 1%至 2%将是异位妊娠。作为导致产妇发病率和死亡率的主要原因之一，异位妊娠的诊断和确定不明位置妊娠的结局具有重要的临床意义。已经独立和联合研究了几种血清和血浆生物标志物用于异位妊娠。以下是异位妊娠和不明位置妊娠的生物标志物发现和开发的研究现状综述。
