Rosenquist Kerstin, Wennerberg Johan, Schildt Elsy-Britt, Bladström Anna, Göran Hansson Bengt, Andersson Gunilla
Department of Oral Surgery and Oral Medicine, Faculty of Odontology, Malmö University, Malmö, Sweden.
Acta Otolaryngol. 2005 Dec;125(12):1327-36. doi: 10.1080/00016480510012273.
Our results show that average and poor oral hygiene and inadequate dental status are independent risk factors for oral and oropharyngeal squamous cell carcinoma (OOSCC), irrespective of tobacco and alcohol consumption.
To evaluate a possible relationship between oral cancer, oral hygiene, dental status, oral mucosal lesions and some lifestyle factors in a population-based case-control study.
Between September 2000 and January 2004, 132/165 (80%) of all incident cases of OOSCC and 320/396 (81%) of the intended eligible matched controls participated in the study. Cases and controls were subjected to an identical oral examination. A standardized protocol specially designed for the study was used.
After adjusting for tobacco and alcohol consumption, average oral hygiene (OR 2.0; 95% CI 1.1-3.6) and poor oral hygiene (OR 5.3; 95% CI 2.5-11.3) emerged as significant risk factors for OOSCC. More than 20 lost teeth (OR 3.4; 95% CI 1.4-8.5), >5 defective teeth (OR 3.1; 95% CI 1.2-8.2) and poorly fitting or defective complete dentures (OR 3.8; 95% CI 1.3-11.4) were significant risk factors. Regular dental check-ups were associated with a decreased risk of OOSCC (OR 0.4; 95% CI 0.2-0.6).
我们的研究结果表明，无论烟草和酒精摄入量如何，口腔卫生状况一般和较差以及牙齿状况不佳都是口腔和口咽鳞状细胞癌（OOSCC）的独立危险因素。
在一项基于人群的病例对照研究中，评估口腔癌、口腔卫生、牙齿状况、口腔黏膜病变与一些生活方式因素之间的可能关系。
2000年9月至2004年1月期间，OOSCC所有新发病例中的132/165（80%）以及320/396（81%）预期符合条件的匹配对照参与了本研究。病例和对照接受了相同的口腔检查。使用了专门为该研究设计的标准化方案。
在对烟草和酒精摄入量进行调整后，口腔卫生状况一般（比值比2.0；95%置信区间1.1 - 3.6）和口腔卫生状况较差（比值比5.3；95%置信区间2.5 - 11.3）成为OOSCC显著的危险因素。超过20颗牙齿缺失（比值比3.4；95%置信区间1.4 - 8.5）、超过5颗牙齿有缺陷（比值比3.1；95%置信区间1.2 - 8.2）以及全口义齿佩戴不合适或有缺陷（比值比3.8；95%置信区间1.3 - 11.4）都是显著的危险因素。定期进行牙齿检查与OOSCC风险降低相关（比值比0.4；95%置信区间0.2 - 0.6）。
