Department of Stomatology Xinjiang Medical University, Affiliated Hospital 2, Urumqi, Xinjiang 830063, China.
Acta Odontol Scand. 2024 May 14;83:40478. doi: 10.2340/aos.v83.40478.
The current studies have yielded inconclusive findings regarding the connection between periodontitis and oral cancer (OC). Therefore, our goal is to elucidate this relationship.
We conducted a thorough search of electronic databases (EMBASE, PubMed, Web of Science, and Cochrane Library) up to September 2023. The Newcastle-Ottawa Scale (NOS) was applied to assess study quality. To evaluate potential publication bias, both a funnel plot and Egger's test were employed. Additionally, a sensitivity analysis was conducted to explore the source of heterogeneity when the I2 statistic exceeded 50%.
This systematic review encompassed 16 studies, involving a total of 6,032 OC patients and 7,432 healthy controls. Our meta-analysis, incorporating data from nine studies, revealed a significant correlation between periodontitis and the risk of OC (OR [odds ratio] = 2.94, 95% CI [confidence interval] (2.13, 4.07); five studies, 6,927 participants; low certainty of evidence). Findings also suggested that individuals with more than 15 missing teeth may have a heightened risk of OC (OR = 1.91, 95% CI (1.01, 3.62)). Furthermore, clinical attachment loss (CAL) and decayed, missing, and filled teeth (DMFT) in OC patients were more pronounced compared to the control group (CAL, SMD = 1.94, 95% CI (0.22, 3.66); DMFT, SMD = 0.65, 95% CI (0.12, 1.18)).
Periodontitis may serve as a potential risk factor for OC. However, caution is warranted in interpreting these findings due to the substantial level of heterogeneity.
目前的研究结果对于牙周炎与口腔癌（OC）之间的关联尚无定论。因此，我们的目标是阐明这种关系。
我们对电子数据库（EMBASE、PubMed、Web of Science 和 Cochrane Library）进行了全面搜索，截至 2023 年 9 月。使用纽卡斯尔-渥太华量表（NOS）评估研究质量。为了评估潜在的发表偏倚，我们同时使用漏斗图和 Egger 检验。此外，当 I²统计量超过 50%时，我们进行了敏感性分析以探索异质性的来源。
这项系统评价纳入了 16 项研究，共纳入 6032 名 OC 患者和 7432 名健康对照者。我们的荟萃分析纳入了 9 项研究的数据，结果显示牙周炎与 OC 的风险之间存在显著相关性（OR [比值比] = 2.94，95%CI [置信区间] （2.13, 4.07）；五项研究，6927 名参与者；证据确定性为低）。研究结果还表明，缺失牙超过 15 颗的个体发生 OC 的风险可能会增加（OR = 1.91，95%CI（1.01, 3.62））。此外，OC 患者的临床附着丧失（CAL）和龋齿、缺失和填充的牙齿（DMFT）明显高于对照组（CAL，SMD = 1.94，95%CI（0.22, 3.66）；DMFT，SMD = 0.65，95%CI（0.12, 1.18））。
牙周炎可能是 OC 的一个潜在危险因素。但是，由于存在很大的异质性，在解释这些发现时需要谨慎。
