Sapkota A, Hsu C C, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Mates D, Fabiánová E, Rudnai P, Janout V, Holcatova I, Brennan P, Boffetta P, Hashibe M
Lifestyle, Environment and Cancer Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69008 Lyon, France.
Cancer Causes Control. 2008 Dec;19(10):1161-70. doi: 10.1007/s10552-008-9183-0. Epub 2008 May 30.
The incidence of squamous cell carcinoma of upper aerodigestive tract (UADT: oral cavity, pharynx, larynx, and esophagus) has been increasing in central and eastern European countries. We investigated the relationship between diet and UADT cancers in these high risk areas.
We used data from hospital-based case-control study of 948 UADT cancer cases and 1,228 controls conducted in Romania, Hungary, Poland, Russia, Slovakia, and Czech Republic. Standardized questionnaire were used to collect information on 23 different food items, along with alcohol and tobacco consumptions. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the UADT cancers after adjusting for center, age, sex, tobacco & alcohol intake, and other food groups.
Consumption of dairy product was negatively associated with selected UADT cancers: larynx (OR: 0.38, CI: 0.23-0.62) and esophagus (OR: 0.55, CI: 0.33-0.93). While consumption of yellow/orange vegetables were inversely associated with oral/pharyngeal and laryngeal cancer (OR: 0.53, CI: 0.35-0.81 and OR: 0.62, CI: 0.38-1.00, respectively), preserved vegetable was positively associated with oral/pharyngeal and laryngeal cancer risk (p (trend) < 0.01 for both).
Specific dietary components may play a role in the development of UADT cancers in the high-risk region of central and eastern Europe.
在中东欧国家，上消化道（UADT：口腔、咽、喉和食管）鳞状细胞癌的发病率一直在上升。我们调查了这些高危地区饮食与UADT癌症之间的关系。
我们使用了在罗马尼亚、匈牙利、波兰、俄罗斯、斯洛伐克和捷克共和国进行的一项基于医院的病例对照研究的数据，该研究纳入了948例UADT癌症病例和1228例对照。使用标准化问卷收集23种不同食物以及酒精和烟草消费的信息。在对中心、年龄、性别、烟草和酒精摄入量以及其他食物组进行调整后，使用逻辑回归计算UADT癌症的比值比（OR）和95%置信区间（CI）。
乳制品消费与特定的UADT癌症呈负相关：喉癌（OR：0.38，CI：0.23 - 0.62）和食管癌（OR：0.55，CI：0.33 - 0.93）。而黄色/橙色蔬菜的消费与口腔/咽癌和喉癌呈负相关（OR分别为：0.53，CI：0.35 - 0.81和OR：0.62，CI：0.38 - 1.00），腌制蔬菜与口腔/咽癌和喉癌风险呈正相关（两者的p（趋势）<0.01）。
特定的饮食成分可能在中东欧高危地区UADT癌症的发生中起作用。
