Strieter Robert M
David Geffen School of Medicine, University of California at Los Angeles, 900 Veteran Avenue, 14-154 Warren Hall, Los Angeles, CA 90095-1786, USA.
Chest. 2005 Nov;128(5 Suppl 1):526S-532S. doi: 10.1378/chest.128.5_suppl_1.526S.
Idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia (UIP) is not well-understood. Current explanations of the natural history and pathogenesis of IPF/UIP are controversial, and ongoing research continues to investigate multiple hypotheses. A complete understanding of the natural history of IPF could potentially help to identify different mechanisms that are operative at the early, intermediate, and end stages of the disease. This knowledge could lead to the development of more effective therapeutic interventions that target stage-specific aberrant pathways involved in IPF/UIP pathogenesis.
特发性肺纤维化（IPF）/普通型间质性肺炎（UIP）的病因尚不明确。目前对IPF/UIP自然史和发病机制的解释存在争议，正在进行的研究仍在探究多种假说。全面了解IPF的自然史可能有助于识别在疾病早期、中期和末期起作用的不同机制。这一知识可能会促使开发出更有效的治疗干预措施，针对IPF/UIP发病机制中特定阶段的异常途径。
