Fann Jesse R, Bombardier Charles H, Dikmen Sureyya, Esselman Peter, Warms Catherine A, Pelzer Erika, Rau Holly, Temkin Nancy
Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle 98195, USA.
J Head Trauma Rehabil. 2005 Nov-Dec;20(6):501-11. doi: 10.1097/00001199-200511000-00003.
To test the validity and reliability of the Patient Health Questionnaire-9 (PHQ-9) for diagnosing major depressive disorder (MDD) among persons with traumatic brain injury (TBI).
Prospective cohort study.
Level I trauma center.
135 adults within 1 year of complicated mild, moderate, or severe TBI.
PHQ-9 Depression Scale, Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (SCID).
Using a screening criterion of at least 5 PHQ-9 symptoms present at least several days over the last 2 weeks (with one being depressed mood or anhedonia) maximizes sensitivity (0.93) and specificity (0.89) while providing a positive predictive value of 0.63 and a negative predictive value of 0.99 when compared to SCID diagnosis of MDD. Pearson's correlation between the PHQ-9 scores and other depression measures was 0.90 with the Hopkins Symptom Checklist depression subscale and 0.78 with the Hamilton Rating Scale for Depression. Test-retest reliability of the PHQ-9 was r = 0.76 and kappa = 0.46 when using the optimal screening method.
The PHQ-9 is a valid and reliable screening tool for detecting MDD in persons with TBI.
检验患者健康问卷-9（PHQ-9）在诊断创伤性脑损伤（TBI）患者的重度抑郁症（MDD）方面的有效性和可靠性。
前瞻性队列研究。
一级创伤中心。
135名在复杂的轻度、中度或重度TBI后1年内的成年人。
PHQ-9抑郁量表、《精神障碍诊断与统计手册》第四版（SCID）结构化临床访谈。
使用在过去2周内至少几天出现至少5个PHQ-9症状（其中一个为情绪低落或快感缺失）的筛查标准，与SCID对MDD的诊断相比，灵敏度（0.93）和特异度（0.89）最高，阳性预测值为0.63，阴性预测值为0.99。PHQ-9得分与其他抑郁测量指标之间的Pearson相关性，与霍普金斯症状清单抑郁分量表为0.90，与汉密尔顿抑郁评定量表为0.78。使用最佳筛查方法时，PHQ-9的重测信度r = 0.76，kappa = 0.46。
PHQ-9是检测TBI患者MDD的有效且可靠的筛查工具。
