Altaf Chauhdry, Ahmed Parvez, Ashraf Tanveer, Anwar Masood, Ahmed Irfan
Armed Forces Institute of Transfusion, Rawalpindi, Azad Kashmir Combined Military Hospital, Muzaffarabad.
J Pak Med Assoc. 2005 Nov;55(11):475-8.
To study the epidemiology and status of resistance to antimonial compounds of paediatric hospital population with visceral leishmaniasis in Muzaffarabad, Azad Jammu and Kashmir, Pakistan.
Children admitted between January to December 1999 in Azad Kashmir Combined Military Hospital Muzaffarabad and diagnosed as Visceral Leishmaniasis by demonstration of Leishmania parasites in bone marrow aspirate were included in the study. Patients received meglumine antimoniate for 21 days. The demographic information and time taken for resolution of fever after initiation of treatment were recorded.
During study period out of 3520 paediatric admissions, 61 patients had visceral leishmaniasis. The frequency of disease was 1.73%. Median age of the patients was 18 months. Eighty two percent cases reported during non-winter seasons. Fifty nine (96.7%) patients responded to treatment with antimonial compounds. Median time taken for resolution of fever was 5.7 days. Two of the patients died during the study period.
Childhood visceral leishmaniasis is common in Muzaffarabad and there is no resistance to antimonial compounds.
研究巴基斯坦阿扎德克什米尔穆扎法拉巴德地区儿科医院内脏利什曼病患者的流行病学情况及对锑剂的耐药状况。
纳入1999年1月至12月在穆扎法拉巴德阿扎德克什米尔联合军事医院住院、经骨髓穿刺涂片发现利什曼原虫而诊断为内脏利什曼病的儿童。患者接受葡甲胺锑酸盐治疗21天。记录人口统计学信息及开始治疗后发热消退所需时间。
在研究期间，3520例儿科住院患者中，61例患有内脏利什曼病。疾病发生率为1.73%。患者的中位年龄为18个月。82%的病例在非冬季报告。59例（96.7%）患者对锑剂治疗有反应。发热消退的中位时间为5.7天。两名患者在研究期间死亡。
儿童内脏利什曼病在穆扎法拉巴德很常见，且对锑剂无耐药性。
