Torre-Cisneros J, Villanueva J L, Kindelan J M, Jurado R, Sanchez-Guijo P
Department of Internal Medicine, Hospital Regional Universitario Reina Sofia, Cordoba, Spain.
Clin Infect Dis. 1993 Oct;17(4):625-7. doi: 10.1093/clinids/17.4.625.
We describe two cases of visceral leishmaniasis in patients infected with human immunodeficiency virus (HIV); both cases were resistant to antimony compounds but were cured with liposomal amphotericin B, with no significant toxicity. A review of the previous reported cases of antimony-resistant visceral leishmaniasis in HIV-infected patients confirmed the effectiveness of treatment with liposomal amphotericin B, which directly targets infected macrophages and reaches high levels in plasma and tissue.
我们描述了两例感染人类免疫缺陷病毒（HIV）的内脏利什曼病患者；这两例患者均对锑化合物耐药，但用脂质体两性霉素B治愈，且无明显毒性。对先前报道的HIV感染患者中耐锑内脏利什曼病病例的回顾证实了脂质体两性霉素B治疗的有效性，该药物直接作用于受感染的巨噬细胞，并在血浆和组织中达到较高水平。
