子宫内膜异位症女性腹膜液中粒细胞趋化蛋白-2浓度升高。
Increased granulocyte chemotactic protein-2 concentrations in peritoneal fluid of women with endometriosis.
作者信息
Suzumori Nobuhiro, Zhao Xaio Xi, Suzumori Kaoru
机构信息
Department of Obstetrics & Gynecology, Nagoya City University Graduate School of Medicine, 1-Kawasumi, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan.
出版信息
Acta Obstet Gynecol Scand. 2005 Dec;84(12):1141-4. doi: 10.1111/j.0001-6349.2005.00680.x.
BACKGROUND
To evaluate the release of granulocyte chemotactic protein-2 (GCP-2) into peritoneal fluid in women with endometriosis, we measured its concentration with reference to the disease stage and the phase of the menstrual cycle.
METHODS
Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle for 64 women with endometriosis (n = 38) or cystadenomas (n = 26). GCP-2 concentrations in the peritoneal fluid were measured using an enzyme-linked immunosorbent assay.
RESULT
Our findings indicated elevated concentrations of GCP-2 in peritoneal fluid from women with endometriosis during the proliferative phase, which were positively correlated with the stage of endometriosis.
CONCLUSION
Inflammation associated with endometriosis may be involved in the pathogenesis of the disease through increasing levels of peritoneal fluid GCP-2.
背景
为了评估子宫内膜异位症女性腹腔液中粒细胞趋化蛋白-2（GCP-2）的释放情况，我们参照疾病分期和月经周期阶段对其浓度进行了测量。
方法
计划在月经周期的增殖期或分泌期对64例患有子宫内膜异位症（n = 38）或囊腺瘤（n = 26）的女性进行手术。使用酶联免疫吸附测定法测量腹腔液中GCP-2的浓度。
结果
我们的研究结果表明，增殖期子宫内膜异位症女性腹腔液中GCP-2浓度升高，且与子宫内膜异位症的分期呈正相关。
结论
与子宫内膜异位症相关的炎症可能通过增加腹腔液中GCP-2的水平参与该疾病的发病机制。
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