Dallera F, Perugini O, Gendarini A, Carinelli G, Grandi G, Jezzi B
Divisione di Lungadegenza Riabilitativa, Ospedale Maggiore di Lodi, Milano.
Minerva Med. 1992 Jun;83(6):399-401.
The Authors describe a 53 year old patient, who, after suffering from asthma over the past 10 years, presented with abdominal pain, diarrhoea, dyspnea, petechias on lower limbs, and subsequently developed fever, polyneuritis, pericardial effusion and renal failure. Laboratory showed elevated IgE, presence of antinuclear antibodies to DNA, serum rheumatoid factor and peripheral eosinophilia. The clinical course was suggestive for systemic vasculitis; lung, skin biopsies and renal angiography confirmed this diagnosis: the association with asthma and eosinophilia fulfill the diagnosis of allergic angiitis and granulomatosis (Churg-Strauss syndrome).
作者描述了一名53岁的患者，该患者在过去10年患有哮喘后，出现腹痛、腹泻、呼吸困难、下肢瘀点，随后发展为发热、多发性神经炎、心包积液和肾衰竭。实验室检查显示IgE升高、存在抗DNA核抗体、血清类风湿因子及外周血嗜酸性粒细胞增多。临床病程提示为系统性血管炎；肺部、皮肤活检及肾血管造影证实了这一诊断：哮喘与嗜酸性粒细胞增多的关联符合变应性血管炎和肉芽肿病（Churg-Strauss综合征）的诊断。
