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用聚酰胺-胺树枝状大分子-RGD缀合物靶向肿瘤血管生成脉管系统。

Tumor angiogenic vasculature targeting with PAMAM dendrimer-RGD conjugates.

作者信息

Shukla Rameshwer, Thomas Thommey P, Peters Jennifer, Kotlyar Alina, Myc Andrzej, Baker James R

机构信息

Michigan Nanotechnology Institute for Medicine and Biological Science, Department of Internal Medicine, Division of Allergy, University of Michigan, Ann Arbor, 48109, USA.

出版信息

Chem Commun (Camb). 2005 Dec 14(46):5739-41. doi: 10.1039/b507350b. Epub 2005 Oct 10.

DOI:10.1039/b507350b
PMID:16307130
Abstract

PAMAM dendrimer-RGD-4C peptide conjugate was synthesized and in vitro targeting efficacy to integrin receptor expressing cells was studied by flow cytometry and confocal microscopy.

摘要

合成了聚酰胺-胺（PAMAM）树枝状大分子-RGD-4C肽缀合物，并通过流式细胞术和共聚焦显微镜研究了其对表达整合素受体细胞的体外靶向效果。

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