Akalu Abebe, Cretu Alexandra, Brooks Peter C
Department of Radiation Oncology, Cancer Institute, New York University School of Medicine, New York, NY 10016, USA.
Expert Opin Investig Drugs. 2005 Dec;14(12):1475-86. doi: 10.1517/13543784.14.12.1475.
The crucial role of cell extracellular matrix communication in angiogenesis is well established; thus, it is not surprising that integrins have gained considerable attention as targets for the treatment of neovascular disease. Given the diversity of ligands and complexity of integrin signalling, a new appreciation for the divergent roles of integrins in angiogenesis is emerging. It is becoming clear that integrins regulate angiogenesis in both a positive and negative manner. New studies have provided a better understanding of integrin structure as it relates to ligand binding and signalling. This new insight has opened exciting possibilities for the design of novel inhibitors for clinical applications. In this review, studies concerning the cooperative interactions between integrins and regulatory molecules and possible new strategies for controlling angiogenesis will be discussed.
细胞外基质通讯在血管生成中的关键作用已得到充分证实；因此，整合素作为治疗新生血管疾病的靶点受到了广泛关注也就不足为奇了。鉴于配体的多样性和整合素信号传导的复杂性，人们对整合素在血管生成中不同作用的认识正在不断更新。越来越明显的是，整合素以正负两种方式调节血管生成。新的研究使我们对整合素与配体结合及信号传导相关的结构有了更好的理解。这一新见解为设计临床应用的新型抑制剂开辟了令人兴奋的可能性。在这篇综述中，将讨论有关整合素与调节分子之间协同相互作用以及控制血管生成可能的新策略的研究。
