Goel Hira Lal, Alam Naved, Johnson Isaac N S, Languino Lucia R
Department of Cancer Biology, Prostate Cancer Discovery and Development Program, Cancer Center, University of Massachusetts Medical School Worcester, MA 01605, USA.
Am J Transl Res. 2009 Apr 20;1(3):211-20.
Integrins are cell surface receptors for extracellular matrix proteins and play a key role in cell survival, proliferation, migration and gene expression. Integrin signaling has been shown to be deregulated in several types of cancer, including prostate cancer. This review is focused on integrin signaling pathways known to be deregulated in prostate cancer and known to promote prostate cancer progression.
整合素是细胞外基质蛋白的细胞表面受体，在细胞存活、增殖、迁移和基因表达中起关键作用。整合素信号传导在包括前列腺癌在内的几种癌症中已被证明失调。本综述聚焦于已知在前列腺癌中失调且已知促进前列腺癌进展的整合素信号通路。
