Granade Timothy C
Division of HIV/AIDS Prevention, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Mailstop D-12, Atlanta, GA 30333, USA.
Expert Rev Anti Infect Ther. 2005 Dec;3(6):957-69. doi: 10.1586/14787210.3.6.957.
The HIV pandemic continues to expand throughout Africa and southern Asia. Despite recent advances in therapy, the primary means of prevention continues to be the identification of infected patients through diagnostic testing, and the provision of counseling services to reduce HIV transmission. In order to facilitate the identification of infected patients, great strides have been made during the past 10 years towards the development of simple, rapid HIV antibody assays that require no specialized equipment, are relatively stable at ambient temperatures and can be easily performed by people who do not have a laboratory background. Evaluations of these assays have shown that when used in multiple assay algorithm strategies, they perform comparably with current laboratory-based methods. Effective global implementation of these tests will require a concerted effort from public and private health agencies, however, expanding the use of these assays can provide a significant opportunity to slow the devastating spread of HIV.
艾滋病毒大流行在非洲和南亚持续蔓延。尽管近期治疗方面取得了进展,但主要的预防手段仍然是通过诊断检测来识别感染患者,并提供咨询服务以减少艾滋病毒传播。为了便于识别感染患者,在过去十年里,在开发简单、快速的艾滋病毒抗体检测方法方面取得了巨大进展,这些检测方法不需要专门设备,在常温下相对稳定,没有实验室背景的人员也能轻松操作。对这些检测方法的评估表明,当用于多种检测算法策略时,它们的表现与当前基于实验室的方法相当。然而,要在全球有效实施这些检测,公共和私营卫生机构需要共同努力,扩大这些检测方法的使用可以提供一个重要机会来减缓艾滋病毒的毁灭性传播。