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开发并实施一种模型,以利用急诊科的诊断快速检测来改善对感染艾滋病毒患者的识别。

Development and implementation of a model to improve identification of patients infected with HIV using diagnostic rapid testing in the emergency department.

作者信息

Haukoos Jason S, Hopkins Emily, Eliopoulos Vassily T, Byyny Richard L, Laperriere Kate A, Mendoza Myles X, Thrun Mark W

机构信息

Departments of Emergency Medicine, Denver Health Medical Center, Denver, CO, USA.

出版信息

Acad Emerg Med. 2007 Dec;14(12):1149-57. doi: 10.1197/j.aem.2007.07.015.

Abstract

OBJECTIVES

Infection with the human immunodeficiency virus (HIV) continues to expand in nontraditional risk groups, and the prevalence of undiagnosed infection remains relatively high in the patient populations of urban emergency departments (EDs). Unfortunately, HIV testing in this setting remains uncommon. The objectives of this study were 1) to develop a physician-based diagnostic rapid HIV testing model, 2) to implement this model in a high-volume urban ED, and 3) to prospectively characterize the patients who were targeted by physicians for testing and determine the proportions who completed rapid HIV counseling, testing, and referral; tested positive for HIV infection; and were successfully linked into medical and preventative care.

METHODS

An interdisciplinary group of investigators developed a model for performing physician-based diagnostic rapid HIV testing in the ED. This model was then evaluated using a prospective cohort study design. Emergency physicians identified patients at risk for undiagnosed HIV infection using clinical judgment and consensus guidelines. Testing was performed by the hospital's central laboratory, and clinical social workers performed pretest and posttest counseling and provided appropriate medical and preventative care referrals, as defined by the model.

RESULTS

Over the 30-month study period, 105,856 patients were evaluated in the ED. Of these, 681 (0.64%; 95% confidence interval [CI] = 0.60% to 0.69%) were identified by physicians and completed rapid HIV counseling, testing, and referral. Of the 681 patients, 15 (2.2%; 95% CI = 1.2% to 3.6%) patients tested positive for HIV infection and 12 (80%; 95% CI = 52% to 96%) were successfully linked into care.

CONCLUSIONS

A physician-based diagnostic HIV testing model was developed, successfully implemented, and sustained in a high-volume, urban ED setting. While the use of this model successfully identified patients with undiagnosed HIV infection in the ED, the overall level of testing remained low. Innovative testing programs, such as nontargeted screening, more specific targeted screening, or alternative hybrid methods, are needed to more effectively identify undiagnosed HIV infection in the ED patient population.

摘要

目的

人类免疫缺陷病毒(HIV)感染在非传统风险人群中持续蔓延,在城市急诊科(ED)的患者群体中,未诊断出的感染患病率仍然相对较高。不幸的是,在这种情况下进行HIV检测的情况仍然不常见。本研究的目的是:1)建立一种基于医生的诊断性快速HIV检测模式;2)在一个繁忙的城市急诊科实施该模式;3)前瞻性地描述医生针对检测的患者特征,并确定完成快速HIV咨询、检测和转诊的比例;检测出HIV感染呈阳性的比例;以及成功转入医疗和预防护理的比例。

方法

一个跨学科的研究小组开发了一种在急诊科进行基于医生的诊断性快速HIV检测的模式。然后使用前瞻性队列研究设计对该模式进行评估。急诊医生利用临床判断和共识指南识别有未诊断出HIV感染风险的患者。检测由医院的中心实验室进行,临床社会工作者进行检测前和检测后咨询,并根据该模式提供适当的医疗和预防护理转诊。

结果

在为期30个月的研究期间,急诊科对105,856名患者进行了评估。其中,681名(0.64%;95%置信区间[CI]=0.60%至0.69%)被医生识别并完成了快速HIV咨询、检测和转诊。在这681名患者中,15名(2.2%;95%CI=1.2%至3.6%)患者HIV感染检测呈阳性,12名(80%;95%CI=52%至96%)成功转入护理。

结论

在一个繁忙的城市急诊科环境中,开发、成功实施并维持了一种基于医生的诊断性HIV检测模式。虽然使用该模式成功地在急诊科识别出了未诊断出HIV感染的患者,但总体检测水平仍然较低。需要创新的检测项目,如非针对性筛查、更具体的针对性筛查或替代混合方法,以更有效地在急诊科患者群体中识别未诊断出的HIV感染。

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